Evidence map›Paper›PMID 22189468›Full record

ArticleHuman heredity2011

Detecting pleiotropy and epistasis using variance components linkage analysis in jPAP.

Sandra J Hasstedt, Alun Thomas

Abstract read
In one paragraph

Article in Human heredity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Genetic variants associated with protein C levels.Journal of thrombosis and haemostasis : JTH · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sandra J HasstedtDepartment of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA. sandy@genetics.utah.edu
Alun Thomas

Funding

MODELS FOR THE GENETIC EPIDEMIOLOGY OF CHRONIC DISEASESR01HD017463 · NICHD · UNIVERSITY OF UTAH · PI HASSTEDT, SANDRA J · 1987 to 2009
$1.7M
Graphical models for linkage disequilibrium in genetic mappingR01GM081417 · NIGMS · UNIVERSITY OF UTAH · PI THOMAS, ALUN · 2007 to 2010
$1.1M
GENETIC MODELS AND METHODOLOGY IN PEDIGREE ANALYSISR23HD017463 · NICHD · UNIVERSITY OF UTAH · PI HASSTEDT, SANDRA J · 1985 to 1985
–
NICHD NIH HHS HD17463NICHD NIH HHS R01 HD017463NIGMS NIH HHS GM081417NIGMS NIH HHS R01 GM081417
6 · The paper itself

Abstract

jPAP (Java Pedigree Analysis Package) performs variance components linkage analysis of either quantitative or discrete traits. Multivariate linkage analysis of two or more traits (all quantitative, all discrete, or any combination) allows the inference of pleiotropy between the traits. The inclusion of multiple quantitative trait loci in linkage analysis allows the inference of epistasis between loci. A user-friendly graphical user interface facilitates the usage of jPAP.

Indexed as

Epistasis, GeneticGenetic LinkageGenetic PleiotropyPedigreeSoftwareAnalysis of VarianceHumansInternetModels, GeneticQuantitative Trait, Heritable

Identifiers

PMID22189468
PMCPMC3267992

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.