ArticleBMJ open2011
Oxytocin during labour and risk of severe postpartum haemorrhage: a population-based, cohort-nested case-control study.
Article in BMJ open, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 240 citations in OpenAlex.
- Maternal and newborn plasma oxytocin levels in response to maternal synthetic oxytocin administration during labour, birth and postpartum - a systematic review with implications for the function of the oxytocinergic system.BMC pregnancy and childbirth · 2023Pooled it
- Duration of the second and third stages of labor and risk of postpartum hemorrhage: a cohort study stratified by parity.BMC pregnancy and childbirth · 2025Trial
- Effect of topical magnesium sulfate on labor duration and childbirth experience: a randomized controlled trial.BMC pregnancy and childbirth · 2024Trial
- Frequency and determinants of misuse of augmentation of labor in France: A population-based study.PloS one · 2021Trial
- Reducing neonatal morbidity by discontinuing oxytocin during the active phase of first stage of labor: a multicenter randomized controlled trial STOPOXY.BMC pregnancy and childbirth · 2020Trial
- Striving for scientific stringency: a re-analysis of a randomised controlled trial considering first-time mothers' obstetric outcomes in relation to birth position.BMC pregnancy and childbirth · 2012Trial
- EMMIs: Engineered Myometrial Microtissues for Direct Quantification of Oxytocin-Induced Contractility.bioRxiv : the preprint server for biology · 2026Article
- Risk Factors for Severe Postpartum Hemorrhage in Vaginal Delivery: A Retrospective Cohort Study.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Increased risk of postpartum hemorrhage in women with endometriosis and adenomyosis: a prospective cohort study.Frontiers in endocrinology · 2026Article
- Association between total oxytocin dose and maternal and neonatal morbidity during labour induction: a retrospective study.BMC pregnancy and childbirth · 2025Observational
- Oxytocin treatment at birth accelerates an epigenetic shift in the oxytocin receptor gene in the maternal brain.BMC pregnancy and childbirth · 2025Article
- Does induction or augmentation of labor increase the risk of postpartum hemorrhage in pregnant women with anemia? A multicenter prospective cohort study in India.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Effect of chronic exogenous oxytocin administration on exercise performance and cardiovagal control in hypobaric hypoxia in rats.Biological research · 2024Article
- Oxytocin is not associated with postpartum hemorrhage in labor augmentation in a retrospective cohort study in the United States.American journal of obstetrics and gynecology · 2024Article
- Association between duration of intrapartum oxytocin exposure and obstetric hemorrhage.Archives of gynecology and obstetrics · 2024Article
- Effects of oxytocin induction on early postpartum hemorrhage, perineal integrity, and breastfeeding: a case-control study.Revista da Associacao Medica Brasileira (1992) · 2023Observational
- Use and Effects of Augmentation of Labor with Oxytocin: A Single-Center, Retrospective, Case-Control Study of 4350 Women in Warsaw, Poland, 2015-2020.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Association between anesthetic method and postpartum hemorrhage in Korea based on National Health Insurance Service data.Anesthesia and pain medicine · 2022Article
- Iron Deficiency Anaemia and Atonic Postpartum Haemorrhage Following Labour.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Literature Review: Physiological Management for Preventing Postpartum Hemorrhage.Healthcare (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives Postpartum haemorrhage (PPH) is a major cause of maternal mortality and morbidity worldwide. Experimental studies support the hypothesis that oxytocin administration during labour, a common although not evidence-based practice, may increase the risk of atonic PPH. The clinical studies, however, are inconclusive. The objectives of this study was to investigate the association between the level of oxytocin exposure during labour and the risk of severe PPH and to explore whether the prophylactic use of oxytocin after birth modifies this association. Design Population-based, cohort-nested case-control study. Setting 106 French hospitals from December 2004 through November 2006. Participants Women with term singleton vaginal deliveries, after an uncomplicated pregnancy. Cases were 1483 women with severe PPH, defined by peripartum change in haemoglobin of ≥4 g/dl or need for blood transfusion. Controls were 1758 women from a random sample of parturients without PPH. Main outcome measures The independent association between the level of oxytocin during labour and the risk of severe PPH was tested and quantified with ORs through two-level multivariable logistic regression modelling. Results Oxytocin was administered during labour to 73% of cases and 61% of controls (crude OR: 1.7, 95% CI 1.5 to 2.0). After adjustment for all potential confounders, oxytocin during labour was associated with a significantly higher risk of severe PPH (adjusted OR: 1.8, 95% CI 1.3 to 2.6) in women who did not receive prophylactic oxytocin after delivery; the OR for haemorrhage increased from 1 to 5 according to the level of oxytocin exposure. In women who had prophylactic oxytocin after delivery, this association was significant only for the highest exposure categories. Conclusions Oxytocin during labour appears to be an independent risk factor for severe PPH. The results emphasise the need for guidelines clarifying the evidence-based indications for this procedure and the minimal useful regimens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.