Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
No laughing matter: intranasal oxytocin administration changes functional brain connectivity during exposure to infant laughter.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 78 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it, 191 citations in OpenAlex.
- The effect of intranasal oxytocin on social reward processing in humans: a systematic review.Frontiers in psychiatry · 2023Pooled it
- Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies.Journal of psychiatry & neuroscience : JPN · 2015Pooled it
- Sniffing around oxytocin: review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy.Translational psychiatry · 2013Pooled it
- Preliminary data on oxytocin modulation of neural reactivity in women to emotional stimuli of children depending on childhood emotional neglect.Developmental psychobiology · 2023Trial
- Intranasal oxytocin modulates the salience network in aging.NeuroImage · 2022Trial
- Oxytocin Administration Increases Proactive Control in Men with Overweight or Obesity: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.Obesity (Silver Spring, Md.) · 2021Trial
- Oxytocin treatment attenuates amygdala activity in autism: a treatment-mechanism study with long-term follow-up.Translational psychiatry · 2020Trial
- Oxytocin induces long-lasting adaptations within amygdala circuitry in autism: a treatment-mechanism study with randomized placebo-controlled design.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Effects of Intranasal Oxytocin on the Blood Oxygenation Level-Dependent Signal in Food Motivation and Cognitive Control Pathways in Overweight and Obese Men.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Intranasal Oxytocin Selectively Modulates Large-Scale Brain Networks in Humans.Brain connectivity · 2017Trial
- Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women.Translational psychiatry · 2017Trial
- Oxytocin modulates hemodynamic responses to monetary incentives in humans.Psychopharmacology · 2016Trial
- Intranasal Oxytocin Affects Amygdala Functional Connectivity after Trauma Script-Driven Imagery in Distressed Recently Trauma-Exposed Individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Amygdala-Hippocampal Connectivity Changes During Acute Psychosocial Stress: Joint Effect of Early Life Stress and Oxytocin.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Oxytocin increases VTA activation to infant and sexual stimuli in nulliparous and postpartum women.Hormones and behavior · 2015Trial
- Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Oxytocin affects the connectivity of the precuneus and the amygdala: a randomized, double-blinded, placebo-controlled neuroimaging trial.The international journal of neuropsychopharmacology · 2014Trial
- Early life stress modulates amygdala-prefrontal functional connectivity: implications for oxytocin effects.Human brain mapping · 2014Trial
- An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- An exploratory fMRI study on the association of parental involvement in childcare with brain responses to infant vocalisations and dyadic interaction quality in same-sex mother families.BMC psychology · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infant laughter is a rewarding experience. It activates neural reward circuits and promotes parental proximity and care, thus facilitating parent-infant attachment. The neuropeptide oxytocin might enhance the incentive salience of infant laughter by modulating neural circuits related to the perception of infant cues. In a randomized controlled trial with functional magnetic resonance imaging we investigated the influence of intranasally administered oxytocin on functional brain connectivity in response to infant laughter. Blood oxygenation level-dependent responses to infant laughter were measured in 22 nulliparous women who were administered oxytocin and 20 nulliparous women who were administered a placebo. Elevated oxytocin levels reduced activation in the amygdala during infant laughter and enhanced functional connectivity between the amygdala and the orbitofrontal cortex, the anterior cingulate, the hippocampus, the precuneus, the supramarginal gyri, and the middle temporal gyrus. Increased functional connectivity between the amygdala and regions involved in emotion regulation may reduce negative emotional arousal while enhancing the incentive salience of the infant laughter.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.