SynthesisBMC systems biology2011
A chemokine gene expression signature derived from meta-analysis predicts the pathogenicity of viral respiratory infections.
Synthesis in BMC systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Tpl2 Ablation Leads to Hypercytokinemia and Excessive Cellular Infiltration to the Lungs During Late Stages of Influenza Infection.Frontiers in immunology · 2021Article
- Influenza-Omics and the Host Response: Recent Advances and Future Prospects.Pathogens (Basel, Switzerland) · 2017Review
- Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine.Molecular neurobiology · 2017Article
- Cytokine Profiles of Severe Influenza Virus-Related Complications in Children.Frontiers in immunology · 2017Article
- H7N9 and other pathogenic avian influenza viruses elicit a three-pronged transcriptomic signature that is reminiscent of 1918 influenza virus and is associated with lethal outcome in mice.Journal of virology · 2014Article
- Moving H5N1 studies into the era of systems biology.Virus research · 2013Review
- Systems approaches to influenza-virus host interactions and the pathogenesis of highly virulent and pandemic viruses.Seminars in immunology · 2013Review
- Bugs in the system.Immunological reviews · 2013Review
- Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice.BMC systems biology · 2013Article
- Article
- Systems virology: host-directed approaches to viral pathogenesis and drug targeting.Nature reviews. Microbiology · 2013Review
- 1918 Influenza virus hemagglutinin (HA) and the viral RNA polymerase complex enhance viral pathogenicity, but only HA induces aberrant host responses in mice.Journal of virology · 2013Article
- Critical dynamics in host-pathogen systems.Current topics in microbiology and immunology · 2013Review
- 2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models.BMC genomics · 2012Article
- 6th International Conference on Emerging Zoonoses.Zoonoses and public health · 2012Article
- Systems biology from virus to humans.Journal of analytical science and technologyReview
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundDuring respiratory viral infections host injury occurs due in part to inappropriate host responses. In this study we sought to uncover the host transcriptional responses underlying differences between high- and low-pathogenic infections.
resultsFrom a compendium of 12 studies that included responses to influenza A subtype H5N1, reconstructed 1918 influenza A virus, and SARS coronavirus, we used meta-analysis to derive multiple gene expression signatures. We compared these signatures by their capacity to segregate biological conditions by pathogenicity and predict pathogenicity in a test data set. The highest-performing signature was expressed as a continuum in low-, medium-, and high-pathogenicity samples, suggesting a direct, analog relationship between expression and pathogenicity. This signature comprised 57 genes including a subnetwork of chemokines, implicating dysregulated cell recruitment in injury.
conclusionsHighly pathogenic viruses elicit expression of many of the same key genes as lower pathogenic viruses but to a higher degree. This increased degree of expression may result in the uncontrolled co-localization of inflammatory cell types and lead to irreversible host damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.