Evidence map›Paper›PMID 22189135›Full record

ArticleBioorganic & medicinal chemistry letters2012

High-affinity fluorescent ligands for the 5-HT(3) receptor.

Jonathan Simonin, Sanjeev Kumar V Vernekar, Andrew J Thompson, J Daniel Hothersall, Christopher N Connolly, Sarah C R Lummis, Martin Lochner

Abstract read
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. 5-HTParasitology research · 2019
    Article
  5. Fluorescent Anesthetics.Methods in enzymology · 2018
    Article
  6. Article
  7. Article
  8. The Environment Shapes the Inner Vestibule of LeuT.PLoS computational biology · 2016
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jonathan SimoninDepartment of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
Sanjeev Kumar V Vernekar
Andrew J Thompson
J Daniel Hothersall
Christopher N Connolly
Sarah C R Lummis
Martin Lochner

Funding

Biotechnology and Biological Sciences Research Council C18896Wellcome Trust 085141
6 · The paper itself

Abstract

The synthesis, photophysical and biological characterization of a small library of fluorescent 5-HT(3) receptor ligands is described. Several of these novel granisetron conjugates have high quantum yields and show high affinity for the human 5-HT(3)AR.

Indexed as

AnimalsChlorocebus aethiopsCOS CellsCrystallography, X-RayDose-Response Relationship, DrugFluorescent DyesHumansLigandsModels, MolecularMolecular StructureReceptors, Serotonin, 5-HT3Small Molecule LibrariesStereoisomerismStructure-Activity RelationshipFluorescent DyesLigandsReceptors, Serotonin, 5-HT3Small Molecule Libraries

Identifiers

PMID22189135
PMCPMC3277886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.