ArticleEnvironmental health perspectives2012
Environmental exposure to polychlorinated biphenyls and p,p'-DDE and sperm sex-chromosome disomy.
Article in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00011713 (Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The environmental and occupational influence of pesticides on male fertility: A systematic review of human studies.Andrology · 2022Pooled it
- In utero and childhood exposure to organochlorines and perfluorinated chemicals in relation to sperm aneuploidy in adulthood.Environmental health : a global access science source · 2026Article
- In utero and childhood exposure to organochlorines and perfluorinated chemicals in relation to sperm aneuploidy in adulthood.Research square · 2025Article
- Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Elevated exposures to persistent endocrine disrupting compounds impact the sperm methylome in regions associated with autism spectrum disorder.Frontiers in genetics · 2022Article
- Endocrine Disruptors Acting on Estrogen and Androgen Pathways Cause Reproductive Disorders through Multiple Mechanisms: A Review.International journal of environmental research and public health · 2021Review
- Article
- Endocrine-Disrupting Air Pollutants and Their Effects on the Hypothalamus-Pituitary-Gonadal Axis.International journal of molecular sciences · 2020Review
- Potential Increased Risk of Trisomy 18 Observed After a Fertilizer Warehouse Fire in Brazos County and TX.International journal of environmental research and public health · 2020Observational
- Carbon nanotube-mediated antibody-free suspension array for determination of typical endocrine-disrupting chemicals.Mikrochimica acta · 2020Article
- Pesticide interactions and risks of sperm chromosomal abnormalities.International journal of hygiene and environmental health · 2019Article
- New Biological Insights on X and Y Chromosome-Bearing Spermatozoa.Frontiers in cell and developmental biology · 2019Review
- Residential distance to major roadways and semen quality, sperm DNA integrity, chromosomal disomy, and serum reproductive hormones among men attending a fertility clinic.International journal of hygiene and environmental health · 2018Article
- Occurrence and risk assessment of persistent organic pollutants in a branch of the Grand Canal in Hangzhou, China.Environmental monitoring and assessment · 2018Article
- Heavy Metal Pollution and Ecological Assessment around the Jinsha Coal-Fired Power Plant (China).International journal of environmental research and public health · 2017Article
- Environmental Contaminants Affecting Fertility and Somatic Health.Seminars in reproductive medicine · 2017Review
- Integrated wetlands for food production.Environmental research · 2016Review
- Sperm Aneuploidy in Faroese Men with Lifetime Exposure to Dichlorodiphenyldichloroethylene (p,p´-DDE) and Polychlorinated Biphenyl (PCB) Pollutants.Environmental health perspectives · 2016Article
- Dialkyl phosphate urinary metabolites and chromosomal abnormalities in human sperm.Environmental research · 2015Article
- Urinary concentrations of benzophenone-type ultraviolet light filters and semen quality.Fertility and sterility · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundChromosomal abnormalities contribute substantially to reproductive problems, but the role of environmental risk factors has received little attention.
objectivesWe evaluated the association of polychlorinated biphenyl (PCB) and dichlorodiphenyldichloroethylene (p,p'-DDE) exposures with sperm sex-chromosome disomy.
methodsWe conducted a cross-sectional study of 192 men from subfertile couples. We used multiprobe fluorescence in situ hybridization (FISH) for chromosomes X, Y, and 18 to determine XX, YY, XY, and total sex-chromosome disomy in sperm nuclei. Serum was analyzed for concentrations of 57 PCB congeners and p,p'-DDE. Poisson regression models were used to calculate incidence rate ratios (IRRs) for disomy by exposure quartiles, controlling for demographic characteristics and semen parameters.
resultsThe median percent disomy was 0.3 for XX and YY, 0.9 for XY, and 1.6 for total sex-chromosome disomy. We observed a significant trend of increasing IRRs for increasing quartiles of p,p'-DDE in XX, XY, and total sex-chromosome disomy, and a significant trend of increasing IRRs for increasing quartiles of PCBs for XY and total sex-chromosome disomy; however, there was a significant inverse association for XX disomy.
conclusionsOur findings suggest that exposure to p,p'-DDE may be associated with increased rates of XX, XY, and total sex-chromosome disomy, whereas exposure to PCBs may be associated with increased rates of YY, XY, and total sex-chromosome disomy. In addition, we observed an inverse association between increased exposure to PCBs and XX disomy. Further work is needed to confirm these findings.
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