ArticleAmerican journal of nephrology2012
Cognitive function and the risk of death in chronic kidney disease.
Article in American journal of nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Association Between Frailty and Cognitive Impairment in Chronic Kidney Disease: A Systematic Review and Meta-Analysis.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026Pooled it
- Cognitive function and 3-year mortality in the very elderly Chinese population with chronic kidney disease.Clinical interventions in aging · 2018Trial
- Predictive value of multimodal functional magnetic resonance imaging for cognitive impairment in patients with non-dialysis chronic kidney disease.Quantitative imaging in medicine and surgery · 2026Article
- Cognitive impairment and health outcomes in non-dialysis chronic kidney disease: a systematic review and meta-analysis.Clinical kidney journal · 2025Article
- Interdisciplinary Care for Geriatric Syndromes in CKD: A Qualitative Study.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- Association between serum 25-hydroxyvitamin D3 level and cognitive impairment in older chronic kidney disease patients.Scientific reports · 2024Article
- Current Status of the Cognitive Impairment in Chronic Kidney Disease.Physical therapy research · 2024Review
- Multimodal Classification Framework Based on Hypergraph Latent Relation for End-Stage Renal Disease Associated with Mild Cognitive Impairment.Bioengineering (Basel, Switzerland) · 2023Article
- Characterizing Topological Properties of Brain Functional Networks Using Multi-Threshold Derivative for End-Stage Renal Disease with Mild Cognitive Impairment.Brain sciences · 2023Article
- The Influence of Healthy Habits on Cognitive Functions in a Group of Hemodialysis Patients.Journal of clinical medicine · 2023Article
- Revisiting risk prediction tools for death and end-stage renal disease in older patients with advanced chronic kidney disease: a prospective study.International urology and nephrology · 2022Observational
- Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study.Neuropsychiatric disease and treatment · 2021Article
- Cognitive Impairment, Chronic Kidney Disease, and 1-Year Mortality in Older Patients Discharged from Acute Care Hospital.Journal of clinical medicine · 2020Article
- Alterations of default mode functional connectivity in individuals with end-stage renal disease and mild cognitive impairment.BMC nephrology · 2019Article
- Orthostatic blood pressure reduction as a possible explanation for memory deficits in dialysis patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- The Cognitive Impact of Chronic Diseases on Functional Capacity in Community-Dwelling Adults.The journal of nursing research : JNR · 2019Article
- Associations of Chronic Kidney Disease Markers with Cognitive Function: A 12-Year Follow-Up Study.Journal of Alzheimer's disease : JAD · 2019Article
- Aberrant cortical thickness in neurologically asymptomatic patients with end-stage renal disease.Neuropsychiatric disease and treatment · 2018Article
- Dementia is a risk factor for major adverse cardiac and cerebrovascular events in elderly Korean patients initiating hemodialysis: a Korean national population-based study.BMC nephrology · 2017Article
- Pre-ESRD Dementia and Post-ESRD Mortality in a Large Cohort of Incident Dialysis Patients.Dementia and geriatric cognitive disorders · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
aimsCognitive impairment is a risk factor for death in dialysis patients and the general population. We sought to determine if cognitive impairment is associated with death in people with non-dialysis-dependent chronic kidney disease (CKD), and if so, whether this relationship is greater in the CKD population compared to the general population.
methodsNational Health and Nutrition Examination Survey-III participants older than 60 years were asked to subtract 3 from 20 five times and to perform immediate and delayed recall of three items. A cognitive score of 0-11 was assigned based on the number of correct responses. Participants were categorized according to cognitive score (11, 9-10, 6-9, and 0-5) and CKD status. Survival analyses were conducted using Cox models.
resultsWithin the CKD subpopulation, those in the lowest cognitive score group had a twofold increased hazard of death compared to those with maximum score. Within the non-CKD subpopulation, those in the lowest cognitive score group had a 46% increased hazard of death compared to those with maximum score. However, the difference in the hazards of death in the CKD and non-CKD subpopulations with the lowest cognitive score was not significant (p = 0.99).
conclusionsLow cognitive score is associated with an increased risk of death in elderly individuals with and without CKD; however, there was no interaction of CKD and low cognitive score in this analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.