ArticleBiology direct2011
CRISPR loci reveal networks of gene exchange in archaea.
Article in Biology direct, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 57 citations in OpenAlex.
- A predicted CRISPR-mediated symbiosis between uncultivated archaea.Nature microbiology · 2023Article
- CRISPR-influenced symbiosis.Nature microbiology · 2023Article
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- The dark side of the ribosome life cycle.RNA biology · 2022Article
- Adaptation induced by self-targeting in a type I-B CRISPR-Cas system.The Journal of biological chemistry · 2020Article
- The Clustered Regularly Interspaced Short Palindromic Repeat System and Argonaute: An Emerging Bacterial Immunity System for Defense Against Natural Transformation?Frontiers in microbiology · 2020Review
- The nuts and bolts of the Haloferax CRISPR-Cas system I-B.RNA biology · 2019Article
- CRISPR-Cas impedes archaeal mating.Nature microbiology · 2019Article
- Pervasive acquisition of CRISPR memory driven by inter-species mating of archaea can limit gene transfer and influence speciation.Nature microbiology · 2019Article
- CRISPR-Cas Systems and the Paradox of Self-Targeting Spacers.Frontiers in microbiology · 2019Review
- Testing the retroelement invasion hypothesis for the emergence of the ancestral eukaryotic cell.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- High tolerance to self-targeting of the genome by the endogenous CRISPR-Cas system in an archaeon.Nucleic acids research · 2017Article
- Dynamics of adaptive immunity against phage in bacterial populations.PLoS computational biology · 2017Article
- Comparative Analysis of theFrontiers in microbiology · 2017Article
- A CRISPR View of Biological Mechanisms.Discoveries (Craiova, Romania) · 2016Review
- Developing a genetic manipulation system for the Antarctic archaeon, Halorubrum lacusprofundi: investigating acetamidase gene function.Scientific reports · 2016Article
- Friendly Fire: Biological Functions and Consequences of Chromosomal Targeting by CRISPR-Cas Systems.Journal of bacteriology · 2016Review
- Survival and Evolution of CRISPR-Cas System in Prokaryotes and Its Applications.Frontiers in immunology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCRISPR (Clustered, Regularly, Interspaced, Short, Palindromic Repeats) loci provide prokaryotes with an adaptive immunity against viruses and other mobile genetic elements. CRISPR arrays can be transcribed and processed into small crRNA molecules, which are then used by the cell to target the foreign nucleic acid. Since spacers are accumulated by active CRISPR/Cas systems, the sequences of these spacers provide a record of the past "infection history" of the organism.
resultsHere we analyzed all currently known spacers present in archaeal genomes and identified their source by DNA similarity. While nearly 50% of archaeal spacers matched mobile genetic elements, such as plasmids or viruses, several others matched chromosomal genes of other organisms, primarily other archaea. Thus, networks of gene exchange between archaeal species were revealed by the spacer analysis, including many cases of inter-genus and inter-species gene transfer events. Spacers that recognize viral sequences tend to be located further away from the leader sequence, implying that there exists a selective pressure for their retention.
conclusionsCRISPR spacers provide direct evidence for extensive gene exchange in archaea, especially within genera, and support the current dogma where the primary role of the CRISPR/Cas system is anti-viral and anti-plasmid defense. OPEN PEER REVIEW: This article was reviewed by: Profs. W. Ford Doolittle, John van der Oost, Christa Schleper (nominated by board member Prof. J Peter Gogarten).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.