Evidence map›Paper›PMID 22188073›Full record

ArticleJournal of the American Geriatrics Society2011

Inflammatory cytokine levels and depressive symptoms in older women in the year after hip fracture: findings from the Baltimore Hip Studies.

Maya E Matheny, Ram R Miller, Michelle D Shardell, William G Hawkes, Eric J Lenze, Jay Magaziner, Denise L Orwig

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Geriatrics Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Frontiers in microbiology · 2023
    Review
  4. Observational
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maya E MathenyDivision of Gerontology, Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA. mmatheny@epi.umaryland.edu
Ram R Miller
Michelle D Shardell
William G Hawkes
Eric J Lenze
Jay Magaziner
Denise L Orwig

Funding

University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ALICE S. RYAN · 2006 to 2026
$28.9M
Sequelae of Hip Fracture in Men: An Epidemiologic StudyR37AG009901 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY · 1992 to 2018
$11.3M
RESEARCH TRAINING IN THE EPIDEMIOLOGY OF AGINGT32AG000262 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI ANN L GRUBER-BALDINI, DENISE L ORWIG · 1998 to 2026
$8.2M
The Epidemiology of Bone Strength and Muscle Composition After Hip Fracture in MeR01AG029315 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY · 2007 to 2011
$4.1M
Determinants of Recovery Following Hip FractureR01AG018668 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MAGAZINER, JAY STEVEN · 2001 to 2004
$2.3M
Consequences of Inflammation on Muscle Following Hip FractureK23AG027746 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MILLER, RAM R · 2008 to 2011
$646k
NIA NIH HHS K23 AG027746NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG018668NIA NIH HHS R01 AG029315NIA NIH HHS R01 AG18668NIA NIH HHS R37 AG009901NIA NIH HHS R37 AG09901NIA NIH HHS T32 AG000262NIA NIH HHS T32 AG00262
6 · The paper itself

Abstract

objectivesTo determine whether interleukin (IL)-6 or soluble tumor necrosis factor alpha receptor 1 (sTNF-αR1) is associated with depressive symptoms in the year after hip fracture.

designProspective cohort.

settingThree Baltimore-area hospitals.

participantsCommunity-dwelling women aged 65 and older admitted with a new, nonpathological fracture of the proximal femur (N = 134). MEASUREMENTS: Two, 6, and 12 months after fracture, serum was analyzed for IL-6 and sTNF-αR1, and depressive symptoms were measured using the 15-item Geriatric Depression Scale (GDS). Generalized estimating equations were used to model the longitudinal relationship between IL-6, sTNF-αR1, and GDS score. Whether lower extremity function, as measured according to the Lower Extremity Gain Scale (LEGS), explained the relationship between IL-6, sTNF-αR1, and GDS score was also examined.

resultsParticipants in the highest categories of IL-6 (≥5.14 pg/mL) and sTNF-αR1 (≥2,421 pg/mL) had the highest GDS scores in the year after fracture (P = .09 for both). Twelve months after fracture, those in the highest IL-6 and sTNF-αR1 categories had GDS scores that were on average 1.9 (95% confidence interval (CI) = 0.4-3.4, P = .01) and 1.4 (95% CI = -0.1-3.0, P = .07) points higher than those in the lowest category, respectively. Adjusting for LEGS score, the mean difference in GDS scores for highest versus lowest IL-6 categories was 1.6 (95% CI = 0.2-3.0, P = .02) points at 12 months.

conclusionResults from these exploratory analyses support a role for inflammation in the pathophysiology of depressive symptoms after hip fracture. Depressive symptoms in the context of high cytokine levels may represent a sickness syndrome that is chronic in some individuals. Further research should establish the cause and effect of this relationship, as well as long-term correlates.

Indexed as

Aged, 80 and overDepressionFemaleHip FracturesHumansInterleukin-6Prospective StudiesReceptors, Tumor Necrosis Factor, Type ITime FactorsInterleukin-6Receptors, Tumor Necrosis Factor, Type I

Identifiers

PMID22188073
PMCPMC3245645

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.