ArticleJournal of neurotrauma2012
Polymorphisms in the brain-derived neurotrophic factor gene influence memory and processing speed one month after brain injury.
Article in Journal of neurotrauma, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Genetic Influences on Patient-Oriented Outcomes in Traumatic Brain Injury: A Living Systematic Review of Non-Apolipoprotein E Single-Nucleotide Polymorphisms.Journal of neurotrauma · 2021Pooled it
- A global collaboration to study intimate partner violence-related head trauma: The ENIGMA consortium IPV working group.Brain imaging and behavior · 2021Pooled it
- Impact of brain-derived neurotrophic factor genetic polymorphism on cognition: A systematic review.Brain and behavior · 2018Pooled it
- Genetic Variants and Persistent Impairment Following Mild Traumatic Brain Injury: A Systematic Review.The Journal of head trauma rehabilitationPooled it
- Impact of repetitive transcranial magnetic stimulation on post-stroke dysmnesia and the role of BDNF Val66Met SNP.Medical science monitor : international medical journal of experimental and clinical research · 2015Trial
- Outcome prediction after mild and complicated mild traumatic brain injury: external validation of existing models and identification of new predictors using the TRACK-TBI pilot study.Journal of neurotrauma · 2015Trial
- Polygenic Score Identifies Athletes at Increased Risk for Slower Recovery After Sport-Related Concussion: A Concussion Assessment, Research, and Education (CARE) Consortium Study.Sports medicine (Auckland, N.Z.) · 2026Article
- Sex and Genotype Affect Mouse Hippocampal Gene Expression in Response to Blast-Induced Traumatic Brain Injury.Molecular neurobiology · 2025Article
- Investigating the role of the brain-derived neurotrophic factor Val66Met polymorphism in repetitive mild traumatic brain injury outcomes in rats.Behavioral and brain functions : BBF · 2025Article
- BDNF: New Views of an Old Player in Traumatic Brain Injury.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- [Risk factors for cancer-related cognitive impairment in breast and colorectal cancer patients who undergo chemotherapy].Anales del sistema sanitario de Navarra · 2023Article
- COMT Val158Met and BDNF Val66Met Single-Nucleotide Polymorphisms Are Not Associated With Emotional Distress One Year After Moderate-Severe Traumatic Brain Injury.Neurotrauma reports · 2023Article
- The Role of BDNF in Experimental and Clinical Traumatic Brain Injury.International journal of molecular sciences · 2021Review
- Genetic Variation and Impact on Outcome in Traumatic Brain Injury: an Overview of Recent Discoveries.Current neurology and neuroscience reports · 2021Review
- Integrative Neuroinformatics for Precision Prognostication and Personalized Therapeutics in Moderate and Severe Traumatic Brain Injury.Frontiers in neurology · 2021Review
- Brain-Derived Neurotrophic Factor Polymorphism Influences Response to Single-Pulse Transcranial Magnetic Stimulation at Rest.Neuromodulation : journal of the International Neuromodulation Society · 2020Article
- Dissociation of BDNF Val66Met polymorphism on neurocognitive functioning in military veterans with and without a history of remote mild traumatic brain injury.The Clinical neuropsychologist · 2020Article
- The neurobiological effects of repetitive head impacts in collision sports.Neurobiology of disease · 2019Review
- Blast-Related Traumatic Brain Injury: Current Concepts and Research Considerations.Journal of experimental neuroscience · 2019Review
- BDNF Val66Met Genetic Polymorphism Results in Poor Recovery Following Repeated Mild Traumatic Brain Injury in a Mouse Model and Treatment With AAV-BDNF Improves Outcomes.Frontiers in neurology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Brain-derived neurotrophic factor (BDNF) plays a role in cognition, as well as neural survival and plasticity. There are several common polymorphisms in the BDNF gene, one of which (rs6265) is an extensively studied non-synonymous coding polymorphism (Val66Met) which has been linked to cognitive performance in healthy controls and some clinical populations. We hypothesized that the Met allele of rs6265 would be associated with poorer cognitive performance in individuals with mild-to-moderate traumatic brain injury, and that other polymorphisms in the BDNF gene would also affect cognition. Genotype at 9 single-nucleotide polymorphisms (SNPs) in the BDNF gene, and measures of speed of information processing, learning, and memory were assessed in 75 patients with mTBI and 38 healthy subjects. Consistent with previous reports, the Met allele of rs6265 was associated with cognition (slower processing speed) in the entire group. Two other SNPs were associated with processing speed in the mTBI group, but both are in linkage disequilibrium with rs6265, and neither remained significant after adjustment for rs6265 status. Within the mTBI group, but not the controls, 4 SNPs, but not rs6265, were associated with memory measures. These associations were not affected by adjustment for rs6265 status. Polymorphisms in BDNF influence cognitive performance shortly after mTBI. The results raise the possibility that a functional polymorphism other than rs6265 may contribute to memory function after mTBI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.