ReviewThe Pan African medical journal2011
Controlling Sickle Cell Disease in Ghana--ethics and options.
Review in The Pan African medical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
- Effect of Health Education Programme on the Knowledge of and Attitude about Sickle Cell Anaemia among Male Secondary School Students in the Jazan Region of Saudi Arabia: Health Policy Implications.BioMed research international · 2019Trial
- Genetic blood disorder status awareness and factors influencing willingness or reluctance to undergo premarital screening among young adults in Ahafo Region, Ghana: a cross-sectional survey.Journal of health, population, and nutrition · 2026Article
- Exploring the quality of life of caregivers of children with sickle cell disease in a secondary health facility in Ghana.Ghana medical journal · 2025Article
- Perceptions of sickle cell disease and genetic counseling among single young adults in Tamale, Ghana.Journal of community genetics · 2025Article
- Sickle cell disease awareness and perception among Christian religious leaders in Accra Metropolis: a qualitative study.Journal of community genetics · 2024Article
- Beliefs negatively mediate adolescents' and adults' knowledge about sickle cell disease prevention and relationship choices; a one-center exploratory study in Central Region, Ghana.Archives of public health = Archives belges de sante publique · 2024Article
- Hospitalizations among children with sickle cell disease enrolled in the Kumasi Sickle Cell Pan African Consortium (SPARCo) database: A cross sectional study.Health science reports · 2023Article
- Assessing knowledge of sickle cell disease and health beliefs on premarital genetic screening among healthcare trainees at a tertiary institution: A cross-sectional study.Health science reports · 2023Article
- Sickle Cell Disease in Children: Knowledge and Home-Based Management Strategies among Caregivers at a Tertiary Facility in Northern Ghana.BioMed research international · 2022Article
- Analysis of clinical presentation, hematological factors, self-reported bed net usage, and malaria burden in sickle cell disease patients.EClinicalMedicine · 2021Article
- Association between pulmonary function and cardiac enzymes in sickle cell disease.American journal of blood research · 2021Article
- Prevalence of positive mental health and functioning among adults with sickle cell disease in Ghana.Ghana medical journal · 2020Article
- Prevalence of sickle cell disorders and malaria infection in children aged 1-12 years in the Volta Region, Ghana: a community-based study.Malaria journal · 2020Article
- Genetic counselling in sickle cell disease: views of single young adults in Ghana.Journal of community genetics · 2020Article
- Hemoglobin Genotypes Modulate Inflammatory Response toFrontiers in immunology · 2020Article
- Sex differences in physical activity among Ghanaian patients with sickle cell disease.The Pan African medical journal · 2019Article
- Tropical Laboratory Initiative: An innovative model for laboratory medicine in rural areas.African journal of laboratory medicine · 2019Article
- Association between eNOS Gene Polymorphism (T786C and VNTR) and Sickle Cell Disease Patients in Ghana.Diseases (Basel, Switzerland) · 2018Article
- Relation Between Religious Perspectives and Views on Sickle Cell Disease Research and Associated Public Health Interventions in Ghana.Journal of genetic counseling · 2018Article
- Levels of Soluble Endothelium Adhesion Molecules and Complications among Sickle Cell Disease Patients in Ghana.Diseases (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sickle Cell Disease (SCD) is a significant public health burden in Ghana. Recent studies indicate that 2% of Ghanaian newborns are affected by SCD; one in three Ghanaians has the hemoglobin S and/or C gene. As a means of controlling the disease, some authorities have recommended prenatal diagnosis (PND) and selective abortion. In the current era, SCD has a good prognosis and fairly reasonable quality of life. Advances in bone marrow transplantation have shown the disease is curable in selected patients. PND and selective abortion therefore raises a myriad of ethical dilemmas which are considered in this review. In the light of the demonstration of improved prognosis in recent times, PND and selective abortion appears to be applying capital punishment to the unborn child for "crimes" only the parents can be responsible for. In this review, we recommend control of SCD on three levels--preconception genetic testing and strategic reproductive choices, PND and education for carrier parents, and holistic management of persons with SCD. We emphasize the critical importance of self-management, especially self-awareness, in assuring a good quality of life for persons with SCD. We believe such an approach is cost-effective, and consistent with sound ethical principles and good conscience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.