ArticleInternational journal of rheumatology2011
Primary biliary cirrhosis associated with systemic sclerosis: diagnostic and clinical challenges.
Article in International journal of rheumatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Overlap of Primary Biliary Cholangitis and Systemic Sclerosis: A Case of Reynolds Syndrome.Clinical case reports · 2026Article
- Systemic sclerosis and primary biliary cholangitis: a systematic review of case-control studies comparing isolated and overlapping disease phenotypes.Journal of scleroderma and related disorders · 2026Article
- Review
- Association of Black Race with Demographic, Comorbidities, and Outcome Variables in Localized Scleroderma Patients: A Retrospective Analysis of the 2017 US National Inpatient Sample.Dermatology practical & conceptual · 2024Article
- Systemic sclerosis and primary biliary cholangitis: Longitudinal data to determine the outcomes.Journal of scleroderma and related disorders · 2023Article
- Systemic sclerosis and primary biliary cholangitis share an antibody population with identical specificity.Clinical and experimental immunology · 2023Article
- Incidence and Predictors of an Abnormal Liver Function Test Among 674 Systemic Sclerosis Patients: A Cohort Study.Open access rheumatology : research and reviews · 2023Article
- Comprehensive autoantibody profiles in systemic sclerosis: Clinical cluster analysis.Frontiers in immunology · 2022Article
- Primary Biliary Cholangitis and CREST Syndrome: A Rare, Overlapping Presentation With a Review of the Literature.Cureus · 2020Article
- The Pathogenesis of Systemic Sclerosis: An Understanding Based on a Common Pathologic Cascade across Multiple Organs and Additional Organ-Specific Pathologies.Journal of clinical medicine · 2020Review
- Nailfold capillaroscopy and autoimmune connective tissue diseases in patients from a Portuguese nailfold capillaroscopy clinic.Rheumatology international · 2020Article
- Liver involvement in rheumatic diseases.Reumatologia · 2020Review
- Systemic sclerosis and primary biliary cholangitis: An overlapping entity?Journal of scleroderma and related disorders · 2019Review
- Gastrointestinal Manifestations of Systemic Sclerosis.Rheumatology (Sunnyvale, Calif.) · 2018Article
- The Role of Invariant NKT in Autoimmune Liver Disease: Can Vitamin D Act as an Immunomodulator?Canadian journal of gastroenterology & hepatology · 2018Review
- From pruritus to CREST syndrome in a middle aged woman.Journal of frailty, sarcopenia and falls · 2017Article
- Capillaroscopy - a role in modern rheumatology.Reumatologia · 2016Review
- Genetics of systemic sclerosis: recent advances.Current opinion in rheumatology · 2015Review
- Potential Roles for Infectious Agents in the Pathophysiology of Primary Biliary Cirrhosis: What's New?Current infectious disease reports · 2013Article
- Sex differences associated with primary biliary cirrhosis.Clinical & developmental immunology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with primary biliary cirrhosis (PBC) often have concurrent limited systemic sclerosis (SSc). Conversely, up to one-fourth of SSc patients are positive for PBC-specific antimitochondrial antibodies (AMA). The mechanisms responsible for the co-occurrence of these diseases are largely unknown. Genetic, epigenetic, environmental, and infectious factors appear to be important for the pathogenesis of the disease, but the hierarchy of events are not well defined. Patients with SSc and PBC have an increased morbidity and mortality compared with the general population, but whether the presence of both diseases in an affected individual worsens the prognosis and/or outcome of either disease is not clear. Some case reports suggested that the presence of SSc in PBC patents is associated with a more favorable prognosis of the liver disease, whereas others report an increased mortality in patients with PBC and SSc compared to patients with PBC alone. This paper discusses the features of patients with PBC-associated SSc. Our aims are to clarify some of the pathogenetic, diagnostic, and clinical challenges that are currently faced in the routine management of these patients. We also intend to provide some practical hints for practitioners that will assist in the early identification of patients with PBC-associated SSc.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.