ArticleDiabetes2012
Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration.
Article in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed.
- Adaptive Responses in Severe Acute Malnutrition: Endocrinology, Metabolomics, Mortality, and Growth.Nutrients · 2025Review
- Growth hormone receptor gene disruption.Vitamins and hormones · 2023Article
- Growth Hormone and Counterregulation in the Pathogenesis of Diabetes.Current diabetes reports · 2022Review
- Mice with gene alterations in the GH and IGF family.Pituitary · 2022Review
- Musculoskeletal Effects of Altered GH Action.Frontiers in physiology · 2022Review
- Mouse models of growth hormone insensitivity.Reviews in endocrine & metabolic disorders · 2021Review
- Growth hormone receptor disrupts glucose homeostasis via promoting and stabilizing retinol binding protein 4.Theranostics · 2021Article
- Effect of growth hormone on insulin signaling.Molecular and cellular endocrinology · 2020Review
- Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice.Aging · 2020Article
- Article
- Integrative Analyses of mRNA Expression Profile RevealFrontiers in genetics · 2020Article
- Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis.iScience · 2019Article
- Loss of growth hormone-mediated signal transducer and activator of transcription 5 (STAT5) signaling in mice results in insulin sensitivity with obesity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Comparative transcriptomic analysis of skeletal muscle tissue during prenatal stages in Tongcheng and Yorkshire pig using RNA-seq.Functional & integrative genomics · 2018Article
- The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects.Frontiers in endocrinology · 2018Review
- Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass.Skeletal muscle · 2017Article
- Article
- SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.The Journal of clinical investigation · 2016Article
- Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice.Endocrinology · 2016Article
- Altered somatotroph feedback regulation improves metabolic efficiency and limits adipose deposition in male mice.Metabolism: clinical and experimental · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Growth hormone (GH) exerts diverse tissue-specific metabolic effects that are not revealed by global alteration of GH action. To study the direct metabolic effects of GH in the muscle, we specifically inactivated the growth hormone receptor (ghr) gene in postnatal mouse skeletal muscle using the Cre/loxP system (mGHRKO model). The metabolic state of the mGHRKO mice was characterized under lean and obese states. High-fat diet feeding in the mGHRKO mice was associated with reduced adiposity, improved insulin sensitivity, lower systemic inflammation, decreased muscle and hepatic triglyceride content, and greater energy expenditure compared with control mice. The obese mGHRKO mice also had an increased respiratory exchange ratio, suggesting increased carbohydrate utilization. GH-regulated suppressor of cytokine signaling-2 (socs2) expression was decreased in obese mGHRKO mice. Interestingly, muscles of both lean and obese mGHRKO mice demonstrated a higher interleukin-15 and lower myostatin expression relative to controls, indicating a possible mechanism whereby GHR signaling in muscle could affect liver and adipose tissue function. Thus, our study implicates skeletal muscle GHR signaling in mediating insulin resistance in obesity and, more importantly, reveals a novel role of muscle GHR signaling in facilitating cross-talk between muscle and other metabolic tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.