ArticleAmino acids2012
Modulation of innate immune-related pathways in nicotine-treated SH-SY5Y cells.
Article in Amino acids, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Effects of Nicotine on SH-SY5Y Cells: An NMR-Based Metabolomic Study.Metabolites · 2025Article
- Temporal proteomic changes induced by nicotine in human cells: A quantitative proteomics approach.Journal of proteomics · 2021Article
- A nonstructural 2B protein of enterovirus A71 increases cytosolic CaJournal of neurovirology · 2020Article
- Prediction of Smoking Behavior From Single Nucleotide Polymorphisms With Machine Learning Approaches.Frontiers in psychiatry · 2020Article
- Modulatory Effects of Nicotine on neuroHIV/neuroAIDS.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2018Review
- Chronic nicotine differentially affects murine transcriptome profiling in isolated cortical interneurons and pyramidal neurons.BMC genomics · 2017Article
- Modulation Effect of HIV-1 Viral Proteins and Nicotine on Expression of the Immune-Related Genes in Brain of the HIV-1 Transgenic Rats.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Article
- Nicotine mediates expression of genes related to antioxidant capacity and oxidative stress response in HIV-1 transgenic rat brain.Journal of neurovirology · 2016Article
- The HIV-1 transgenic rat model of neuroHIV.Brain, behavior, and immunity · 2015Review
- Argon Mediates Anti-Apoptotic Signaling and Neuroprotection via Inhibition of Toll-Like Receptor 2 and 4.PloS one · 2015Article
- Low dose nicotine attenuates Aβ neurotoxicity through activation early growth response gene 1 pathway.PloS one · 2015Article
- Gene expression and highly diluted molecules.Frontiers in pharmacology · 2014Article
- Vagus nerve through α7 nAChR modulates lung infection and inflammation: models, cells, and signals.BioMed research international · 2014Article
- Identification and characterization of poly(I:C)-induced molecular responses attenuated by nicotine in mouse macrophages.Molecular pharmacology · 2013Article
- Article
- Transcriptome sequencing of gene expression in the brain of the HIV-1 transgenic rat.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Although nicotine has a broad impact on both the central and peripheral nervous systems, the molecular mechanisms remain largely unknown, especially at the signaling pathway level. To investigate that aspect, we employed both conventional molecular techniques, such as quantitative real-time PCR and Western blotting analysis, and high-throughput microarray approach to identify the genes and signaling pathways that are modulated by nicotine. We found 14 pathways significantly altered in SH-SY5Y neuroblastoma cells. Of these, the Toll-like receptor pathway (TLR; p = 2.57 × 10(-4)) is one of the most important innate immune pathways. The death receptor pathway (DR; p = 8.71 × 10(-4)), whose transducers coordinate TLR signals and help conduct the host immune response to infection, was also significantly changed by nicotine. Furthermore, we found that several downstream pathways of TLR and DR signaling, such as PI3K/AKT signaling (p = 9.55 × 10(-6)), p38 signaling (p = 2.40 × 10(-6)), and ERK signaling (p = 1.70 × 10(-4)), were also significantly modulated by nicotine. Interestingly, most of the differentially expressed genes in these pathways leading to nuclear factor κB (NF-κB) activation and those important inhibitors of pathways leading to apoptosis, including FLIP and Bcl-2, were up-regulated by nicotine. Taken together, our findings demonstrate that nicotine can regulate multiple innate immune-related pathways, and our data thus provide new clues to the molecular mechanisms underlying nicotine's regulatory effects on neurons.
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