ArticleEuropean journal of clinical pharmacology2012
Drug-induced immune thrombocytopaenia: results from the Berlin Case-Control Surveillance Study.
Article in European journal of clinical pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Pooled it
- Vaccines for preventing influenza in healthy adults.The Cochrane database of systematic reviews · 2018Pooled it
- A systematic evaluation of laboratory testing for drug-induced immune thrombocytopenia.Journal of thrombosis and haemostasis : JTH · 2013Pooled it
- The potential of antimicrobials to induce thrombocytopenia in critically ill patients: data from a randomized controlled trial.PloS one · 2013Trial
- Pharmacovigilance and clinical insights into perindopril-induced thrombocytopenia: a case report of diagnostic challenges and therapeutic alternatives.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026Article
- Association Between Influenza Vaccine and Immune Thrombocytopenia: A Systematic Review and Meta-Analysis.Vaccines · 2024Review
- Tirofiban-induced thrombocytopenia.Annals of medicine · 2023Review
- Article
- COVID-19 vaccination and immune thrombocytopenia: Cause for vigilance, but not panic.Research and practice in thrombosis and haemostasis · 2023Article
- Thrombosis and thrombocytopenia after vaccination against and infection with SARS-CoV-2 in the United Kingdom.Nature communications · 2022Article
- SARS-CoV-2 vaccination in patients with autoimmune cytopenias: The experience of a reference center.American journal of hematology · 2021Article
- Is the increase in eltrombopag dose cause of myocardial infarction?Anatolian journal of cardiology · 2021Article
- Severe, Refractory Immune Thrombocytopenia Occurring After SARS-CoV-2 Vaccine.Journal of blood medicine · 2021Article
- Targeted resequencing of a locus for heparin-induced thrombocytopenia on chromosome 5 identified in a genome-wide association study.Journal of molecular medicine (Berlin, Germany) · 2018Article
- Prescription medication use and antinuclear antibodies in the United States, 1999-2004.Journal of autoimmunity · 2018Article
- Article
- A Case of Hyperacute Severe Thrombocytopenia Occurring Less than 24 Hours after Intravenous Tirofiban Infusion.Case reports in hematology · 2018Article
- Postinfluenza Vaccination Idiopathic Thrombocytopenic Purpura in Three Elderly Patients.Case reports in hematology · 2016Article
- Mechanism of quinine-dependent monoclonal antibody binding to platelet glycoprotein IIb/IIIa.Blood · 2015Article
- Seasonal Association of Immune Thrombocytopenia in Adults.Balkan medical journal · 2015Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDrug-induced immune thrombocytopaenia is a rare, serious condition that can be triggered by numerous medications. To characterize the spectrum of drugs associated with immune thrombocytopaenia (ITP) in the Berlin Case-Control Surveillance Study (FAKOS).
methodsAdult hospitalized patients with new onset idiopathic, secondary or drug-induced acute ITP and hospital control patients were ascertained by active surveillance in 50 Berlin hospitals (>180 clinical departments) between 2000 and 2009. Drug exposures were obtained in a personal interview. Chronic cases were excluded in a follow-up after 6 or more months. A standardized causality assessment was conducted for each ITP patient to assess possible drug aetiology. Drug risks were quantified in a case-control design with unconditional logistic regression analysis.
resultsNinety out of 169 validated cases of acute ITP were assessed as being at least possibly drug-related (n= 85 different drugs overall, n = 30 drugs with certain or probable causality). Drugs involved in ≥ 2 cases with a probable or certain relationship were tirofiban (n = 10 cases), abciximab (n = 4), trimethoprim/sulphamethoxazole (n = 4), influenza vaccine (n = 3), and citalopram (n = 2). Pneumococcal and poliomyelitis vaccine were assessed as probably causing ITP in one case each. In the case-control analyses, significantly increased risks were observed for tirofiban, abciximab, trimethoprim/sulphamethoxazole, gentamicin, triamterene/hydrochlorothiazide, drospirenone/ethinylestradiol, and influenza vaccination.
conclusionsOur study confirms known ITP risks for glycoprotein IIb/IIIa receptor antagonists and sulphonamides and generates signals for several other drugs and vaccines. New onset of ITP should not only direct attention to drugs as possible aetiological agents, but also to vaccines that are known to cause autoimmune phenomena.
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