ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Indirubin-3-monoxime exhibits anti-inflammatory properties by down-regulating NF-κB and JNK signaling pathways in lipopolysaccharide-treated RAW264.7 cells.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Viral Induced Oxidative and Inflammatory Response in Alzheimer's Disease Pathogenesis with Identification of Potential Drug Candidates: A Systematic Review using Systems Biology Approach.Current neuropharmacology · 2019Pooled it
- Article
- Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential.Biomolecules · 2021Review
- Molluscan Compounds Provide Drug Leads for the Treatment and Prevention of Respiratory Disease.Marine drugs · 2020Review
- Chemical modulation of circadian rhythms and assessment of cellular behavior via indirubin and derivatives.Methods in enzymology · 2020Article
- Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods.Marine drugs · 2018Review
- NF-κB potentiates tumor growth by suppressing a novel target LPTS.Cell communication and signaling : CCS · 2017Article
- Indirubin improves antioxidant and anti-inflammatory functions in lipopolysaccharide-challenged mice.Oncotarget · 2017Article
- Anti-Inflammatory Activity and Structure-Activity Relationships of Brominated Indoles from a Marine Mollusc.Marine drugs · 2017Article
- Indirubin Treatment of Lipopolysaccharide-Induced Mastitis in a Mouse Model and Activity in Mouse Mammary Epithelial Cells.Mediators of inflammation · 2017Article
- Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice.Frontiers in molecular neuroscience · 2017Article
- Anti-inflammatory effects of indirubin derivatives on influenza A virus-infected human pulmonary microvascular endothelial cells.Scientific reports · 2016Article
- Are the Traditional Medical Uses of Muricidae Molluscs Substantiated by Their Pharmacological Properties and Bioactive Compounds?Marine drugs · 2015Review
- Identification of a cell-penetrating peptide domain from human beta-defensin 3 and characterization of its anti-inflammatory activity.International journal of nanomedicine · 2015Article
- Combined Effects of Muricid Extract and 5-Fluorouracil on Intestinal Toxicity in Rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Qing-dai powder promotes recovery of colitis by inhibiting inflammatory responses of colonic macrophages in dextran sulfate sodium-treated mice.Chinese medicine · 2015Article
- AP-1-Targeting Anti-Inflammatory Activity of the Methanolic Extract of Persicaria chinensis.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Indirubin-3'-monoxime exerts a dual mode of inhibition towards leukotriene-mediated vascular smooth muscle cell migration.Cardiovascular research · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIndirubin-3-monoxime (I3M), an indirubin analogue that shows favorable inhibitory activity targeting cyclin-dependent kinase and glycogen synthase kinase, exhibits various biological properties, including chemopreventive, antiangiogenic, and neuropreventive activities. In the present study, we investigated the ability of I3M to regulate inflammatory reactions in macrophages.
methodsThe effects of I3M on inflammation, lipopolysaccharide (LPS)-induced releases of inflammatory mediators, nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling was examined by ELISA and Western blotting analysis.
resultsI3M suppressed not only the generation of nitric oxide (NO) and prostaglandin E(2) but also the expression of inducible NO synthase and cyclooxygenase-2 induced by LPS. Similarly, I3M inhibited the release of pro-inflammatory cytokines induced by LPS in RAW264.7 cells, including interleukin (IL)-1β and IL-6. The underlying mechanism of I3M on anti-inflammatory action was correlated with down-regulation of the NF-κB and MAPK activation.
conclusionsOur data collectively indicate that I3M inhibited the production of several inflammatory mediators and might be used for the treatment of various inflammatory diseases.
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