ArticleImmunogenetics2012
Organization, complexity and allelic diversity of the porcine (Sus scrofa domestica) immunoglobulin lambda locus.
Article in Immunogenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Comparative analysis of the organization and complexity of immunoglobulin light chain loci in equids.Journal of animal science · 2026Article
- A genome assembly and transcriptome atlas of the inbred Babraham pig to illuminate porcine immunogenetic variation.Immunogenetics · 2024Article
- Annotation and characterization of immunoglobulin loci and CDR3 polymorphism in water buffalo (Frontiers in immunology · 2024Article
- IMGTBiomolecules · 2022Article
- Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species.Frontiers in immunology · 2022Review
- A specific promoter-type in ribonuclease L gene is associated with phagocytic activity in pigs.The Journal of veterinary medical science · 2021Article
- Protective porcine influenza virus-specific monoclonal antibodies recognize similar haemagglutinin epitopes as humans.PLoS pathogens · 2021Article
- Immunoglobulins or Antibodies: IMGTBiomedicines · 2020Review
- Next-generation sequencing and single-cell RT-PCR reveal a distinct variable gene usage of porcine antibody repertoire following PEDV vaccination.Science China. Life sciences · 2020Article
- The antibody loci of the domestic goat (Capra hircus).Immunogenetics · 2018Article
- Comprehensive annotation and evolutionary insights into the canine (Canis lupus familiaris) antigen receptor loci.Immunogenetics · 2018Article
- Immunoglobulin Light Chain Gene Rearrangements, Receptor Editing and the Development of a Self-Tolerant Antibody Repertoire.Frontiers in immunology · 2018Review
- Genomic variation in the porcine immunoglobulin lambda variable region.Immunogenetics · 2016Article
- Breed-specific transcriptome response of spleen from six to eight week old piglet after infection with Streptococcus suis type 2.Molecular biology reports · 2014Article
- Characterization of a polymorphic IGLV gene in pigs (Sus scrofa).Immunogenetics · 2014Article
- Advances in swine immunology help move vaccine technology forward.Veterinary immunology and immunopathology · 2014Review
- Structural and functional annotation of the porcine immunome.BMC genomics · 2013Article
- Article
- Immunoglobulin genes and diversity: what we have learned from domestic animals.Journal of animal science and biotechnology · 2012Article
- The porcine antibody repertoire: variations on the textbook theme.Frontiers in immunology · 2012Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
We have characterized the organization, complexity, and expression of the porcine (Sus scrofa domestica) immunoglobulin lambda (IGL) light chain locus, which accounts for about half of antibody light chain usage in swine, yet is nearly totally unknown. Twenty-two IGL variable (IGLV) genes were identified that belong to seven subgroups. Nine genes appear to be functional. Eight possess stop codons, frameshifts, or both, and one is missing the V-EXON. Two additional genes are missing an essential cysteine residue and are classified as ORF (open reading frame). The IGLV genes are organized in two distinct clusters, a constant (C)-proximal cluster dominated by genes similar to the human IGLV3 subgroup, and a C-distal cluster dominated by genes most similar to the human IGLV8 and IGLV5 subgroups. Phylogenetic analysis reveals that the porcine IGLV8 subgroup genes have recently expanded, suggesting a particularly effective role in immunity to porcine-specific pathogens. Moreover, expression of IGLV genes is nearly exclusively restricted to the IGLV3 and IGLV8 genes. The constant locus comprises three tandem cassettes comprised of a joining (IGLJ) gene and a constant (IGLC) gene, whereas a fourth downstream IGLJ gene has no corresponding associated IGLC gene. Comparison of individual BACs generated from the same individual revealed polymorphisms in IGLC2 and several IGLV genes, indicating that allelic variation in IGLV further expands the porcine antibody light chain repertoire.
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