Evidence map›Paper›PMID 22186768›Full record

ArticleMedical care2012

Facility characteristics do not explain higher false-positive rates in diagnostic mammography at facilities serving vulnerable women.

L Elizabeth Goldman, Rod Walker, Diana L Miglioretti, Rebecca Smith-Bindman, And Karla Kerlikowske, Breast Cancer Surveillance Consortium

Abstract read
In one paragraph

Article in Medical care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

L Elizabeth GoldmanDepartment of Medicine, University of California San Francisco, San Francisco, CA 94110, USA. legoldman@medsfgh.ucsf.edu
Rod Walker
Diana L Miglioretti
Rebecca Smith-Bindman
And Karla Kerlikowske
Breast Cancer Surveillance Consortium

Funding

CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
Statistical Coordinating Center for the Breast Cancer Surveillance ConsortiumU01CA086076 · NCI · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI MIGLIORETTI, DIANA L · 2000 to 2011
$8.5M
IMPROVING THE QUALITY OF MAMMOGRAPHIC INTERPRETATIONU01CA063731 · NCI · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI BUIST, DIANA SM · 1994 to 2011
$6.7M
VERMONT BREAST CANCER SURVEILLANCE SYSTEMU01CA070013 · NCI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI GELLER, BERTA M · 1995 to 2011
$6.7M
UTILITY AND OUTCOMES FROM MAMMOGRAPHY IN NORTH CAROLINAU01CA070040 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YANKASKAS, BONNIE C · 1995 to 2011
$6.4M
San Francisco Mammography Registry-A Research SourceU01CA063740 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KERLIKOWSKE, KARLA M · 1994 to 2011
$6.2M
STRATEGIC STUDIES IN BREAST CANCER SURVEILLANCEU01CA086082 · NCI · DARTMOUTH COLLEGE · PI ONEGA, TRACY · 2000 to 2011
$4.9M
REFERRAL PATTERNS AND COST ANALYSIS OF SCREENING MAMMOGRAPHY--FOLLOW-UP/BIOPSYU01CA063736 · NCI · COOPER INSTITUTE · PI CUTTER, GARY · 1994 to 2004
$2.7M
NEW MEXICO MAMMOGRAPHY PROJECTU01CA069976 · NCI · UNIVERSITY OF NEW MEXICO · PI ROSENBERG, ROBERT D · 1995 to 2005
$2.7M
Risk of Cancer in Incidental Findings Identified on Ultrasound ImagingK24CA125036 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SMITH-BINDMAN, REBECCA · 2008 to 2013
$816k
Evaluating and Improving Present-On-Admission for Performance ReportingK08HS018090 · AHRQ · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOLDMAN, LAUREN ELIZABETH · 2009 to 2013
$703k
AHRQ HHS 1 K08HS018090-01AHRQ HHS K08 HS018090NCI NIH HHS K24 CA125036NCI NIH HHS U01 CA063731NCI NIH HHS U01 CA063736NCI NIH HHS U01 CA063740NCI NIH HHS U01 CA069976NCI NIH HHS U01 CA070013NCI NIH HHS U01 CA070040NCI NIH HHS U01 CA086076NCI NIH HHS U01 CA086082NCI NIH HHS U01CA63731NCI NIH HHS U01CA63736NCI NIH HHS U01CA63740NCI NIH HHS U01CA69976NCI NIH HHS U01CA70013NCI NIH HHS U01CA70040NCI NIH HHS U01CA86076NCI NIH HHS U01CA86082NCRR NIH HHS KL2 RR024130
6 · The paper itself

Abstract

backgroundFacilities serving vulnerable women have higher false-positive rates for diagnostic mammography than facilities serving nonvulnerable women. False positives lead to anxiety, unnecessary biopsies, and higher costs.

objectiveExamine whether availability of on-site breast ultrasound or biopsy services, academic medical center affiliation, or profit status explains differences in false-positive rates.

designWe examined 78,733 diagnostic mammograms performed to evaluate breast problems at Breast Cancer Surveillance Consortium facilities from 1999 to 2005. We used logistic-normal mixed effects regression to determine if adjusting for facility characteristics accounts for observed differences in false-positive rates. MEASURES: Facilities were characterized as serving vulnerable women based on the proportion of mammograms performed on racial/ethnic minorities, women with lower educational attainment, limited household income, or rural residence.

resultsAlthough the availability of on-site ultrasound and biopsy services was associated with greater odds of a false positive in most models [odds ratios (OR) ranging from 1.24 to 1.88; P<0.05], adjustment for these services did not attenuate the association between vulnerability and false-positive rates. Estimated ORs for the effect of vulnerability indexes on false-positive rates unadjusted for facility services were: lower educational attainment [OR 1.33; 95% confidence intervals (CI), 1.03-1.74]; racial/ethnic minority status (OR 1.33; 95% CI, 0.98-1.80); rural residence (OR 1.56; 95% CI, 1.26-1.92); limited household income (OR 1.38; 95% CI, 1.10-1.73). After adjustment, estimates remained relatively unchanged.

conclusionsOn-site diagnostic service availability may contribute to unnecessary biopsies, but does not explain the higher diagnostic mammography false-positive rates at facilities serving vulnerable women.

Indexed as

Vulnerable PopulationsAcademic Medical CentersAdultAgedAged, 80 and overBiopsyBreast NeoplasmsFalse Positive ReactionsFemaleHealth FacilitiesHealth Facility AdministrationHumansMammographyMass ScreeningMiddle AgedQuality of Health Care

Identifiers

PMID22186768
PMCPMC3422679

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.