ArticleDevelopment (Cambridge, England)2012
Clonal and molecular analysis of the prospective anterior neural boundary in the mouse embryo.
Article in Development (Cambridge, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis.bioRxiv : the preprint server for biology · 2026Article
- Organizers in a dish: Modeling human CNS morphogenesis.Developmental cell · 2026Review
- A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate.eLife · 2025Article
- An ancient apical patterning system sets the position of the forebrain in chordates.Science advances · 2025Article
- Identification of an embryonic differentiation stage marked by Sox1 and FoxA2 co-expression using combined cell tracking and high dimensional protein imaging.Nature communications · 2024Article
- Wnt signal-dependent antero-posterior specification of early-stage CNS primordia modeled in EpiSC-derived neural stem cells.Frontiers in cell and developmental biology · 2023Article
- Embryonic and extraembryonic tissues during mammalian development: shifting boundaries in time and space.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Shaping axial identity during human pluripotent stem cell differentiation to neural crest cells.Biochemical Society transactions · 2022Article
- Bioengineered embryoids mimic post-implantation development in vitro.Nature communications · 2021Article
- Article
- Cadherins in early neural development.Cellular and molecular life sciences : CMLS · 2021Review
- Neuromesodermal Lineage Contribution to CNS Development in Invertebrate and Vertebrate Chordates.Genes · 2021Review
- Developmental Genes and Malformations in the Hypothalamus.Frontiers in neuroanatomy · 2020Review
- Neuro-mesodermal progenitors (NMPs): a comparative study between pluripotent stem cells and embryo-derived populations.Development (Cambridge, England) · 2019Article
- An epiblast stem cell-derived multipotent progenitor population for axial extension.Development (Cambridge, England) · 2019Article
- Transcriptionally dynamic progenitor populations organised around a stable niche drive axial patterning.Development (Cambridge, England) · 2019Article
- Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells.Stem cell reports · 2018Article
- Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling.Development (Cambridge, England) · 2018Article
- Oct4 regulates the embryonic axis and coordinates exit from pluripotency and germ layer specification in the mouse embryo.Development (Cambridge, England) · 2018Article
- Article
Corrections and comments
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the mouse embryo the anterior ectoderm undergoes extensive growth and morphogenesis to form the forebrain and cephalic non-neural ectoderm. We traced descendants of single ectoderm cells to study cell fate choice and cell behaviour at late gastrulation. In addition, we provide a comprehensive spatiotemporal atlas of anterior gene expression at stages crucial for anterior ectoderm regionalisation and neural plate formation. Our results show that, at late gastrulation stage, expression patterns of anterior ectoderm genes overlap significantly and correlate with areas of distinct prospective fates but do not define lineages. The fate map delineates a rostral limit to forebrain contribution. However, no early subdivision of the presumptive forebrain territory can be detected. Lineage analysis at single-cell resolution revealed that precursors of the anterior neural ridge (ANR), a signalling centre involved in forebrain development and patterning, are clonally related to neural ectoderm. The prospective ANR and the forebrain neuroectoderm arise from cells scattered within the same broad area of anterior ectoderm. This study establishes that although the segregation between non-neural and neural precursors in the anterior midline ectoderm is not complete at late gastrulation stage, this tissue already harbours elements of regionalisation that prefigure the later organisation of the head.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.