Evidence map›Paper›PMID 22186715›Full record

ArticleMolecular & cellular proteomics : MCP2012

PEAKS DB: de novo sequencing assisted database search for sensitive and accurate peptide identification.

Jing Zhang, Lei Xin, Baozhen Shan, Weiwu Chen, Mingjie Xie, Denis Yuen, Weiming Zhang, Zefeng Zhang, Gilles A Lajoie, Bin Ma

Abstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 531 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
531citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

531 citing papers in PubMed, 1 synthesis or guideline pooled it.

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471 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jing ZhangBioinformatics Solutions Inc., Waterloo, Ontario N2L 6J2, Canada.
Lei Xin
Baozhen Shan
Weiwu Chen
Mingjie Xie
Denis Yuen
Weiming Zhang
Zefeng Zhang
Gilles A Lajoie
Bin Ma

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many software tools have been developed for the automated identification of peptides from tandem mass spectra. The accuracy and sensitivity of the identification software via database search are critical for successful proteomics experiments. A new database search tool, PEAKS DB, has been developed by incorporating the de novo sequencing results into the database search. PEAKS DB achieves significantly improved accuracy and sensitivity over two other commonly used software packages. Additionally, a new result validation method, decoy fusion, has been introduced to solve the issue of overconfidence that exists in the conventional target decoy method for certain types of peptide identification software.

Indexed as

Databases, ProteinPeptidesProtein Processing, Post-TranslationalSequence Analysis, ProteinSoftwareTandem Mass SpectrometryPeptides

Identifiers

PMID22186715
PMCPMC3322562

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.