ReviewCurrent opinion in organ transplantation2012
Memory T cells and their exhaustive differentiation in allograft tolerance and rejection.
Review in Current opinion in organ transplantation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Allospecific splenic Tr1 cells drive effector T cell exhaustion through up-regulated Areg-EGFR signaling to promote transplant tolerance.Science advances · 2026Article
- T-cell exhaustion in immune-mediated inflammatory diseases: New implications for immunotherapy.Frontiers in immunology · 2022Review
- Memory T Cells in Transplantation: Old Challenges Define New Directions.Transplantation · 2020Review
- Triptolide inhibits CD4Experimental and therapeutic medicine · 2017Article
- Lymphocyte activation gene 3: a novel therapeutic target in chronic lymphocytic leukemia.Haematologica · 2017Article
- Cardiomyocytes display low mitochondrial priming and are highly resistant toward cytotoxic T-cell killing.European journal of immunology · 2016Article
- The Evolving Roles of Memory Immune Cells in Transplantation.Transplantation · 2015Review
- T-cell exhaustion in allograft rejection and tolerance.Current opinion in organ transplantation · 2015Review
- Immunological considerations in in utero hematopoetic stem cell transplantation (IUHCT).Frontiers in pharmacology · 2014Review
- Endogenous memory CD8 T cells are activated within cardiac allografts without mediating rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013Article
- Memory T cells in transplantation - progress and challenges.Current opinion in organ transplantation · 2013Review
- Role of the PD-1 pathway in the immune response.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewMemory T cells have emerged as a major threat to transplant survival; they are well equipped and well positioned to respond to antigens in an accelerated fashion. They participate in transplant rejection and resist interventions that usually contain naïve T cells. Thus, the means to prevent memory T cells from attacking allotransplants are an important issue in transplantation. RECENT
findingsRecent studies in other models suggest that effector T cells, which include both freshly activated T cells and memory T cells, can acquire 'an exhausted phenotype' in that they progressively lose their effector activities. This response is highly regulated, antigen specific, and driven primarily by antigen persistence. This exhausted phenotype has not been carefully explored in transplant models, and its role in transplant survival remains largely unknown. SUMMARY: Studies of T-cell exhaustion may reveal additional facets of the fundamental mechanisms of transplant survival. T-cell exhaustion may be an alternative way of preventing memory development. Future studies are needed to further improve our understanding of T-cell exhaustion in transplantation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.