ArticleArchives of oral biology2012
Bmp signalling in filiform tongue papillae development.
Article in Archives of oral biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Taste papilla cell differentiation requires the regulation of secretory protein production by ALK3-BMP signaling in the tongue mesenchyme.Development (Cambridge, England) · 2023Article
- Diode Laser in the Management of Foliate Papillitis - Two Case Reports.Journal of pharmacy & bioallied sciences · 2023Article
- Increased activity of mesenchymal ALK2-BMP signaling causes posteriorly truncated microglossia and disorganization of lingual tissues.Genesis (New York, N.Y. : 2000) · 2020Article
- Ablation of NTPDase2+ cells inhibits the formation of filiform papillae in tongue tip.Animal models and experimental medicine · 2018Article
- Serum starvation-induces down-regulation of Bcl-2/Bax confers apoptosis in tongue coating-related cells in vitro.Molecular medicine reports · 2018Article
- An Update on the Sense of Taste in Chickens: A Better Developed System than Previously Appreciated.Journal of nutrition & food sciences · 2018Article
- RNA-Seq analysis on chicken taste sensory organs: An ideal system to study organogenesis.Scientific reports · 2017Article
- Coevolutionary patterning of teeth and taste buds.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Smad1 and 5 but not Smad8 establish stem cell quiescence which is critical to transform the premature hair follicle during morphogenesis toward the postnatal state.Stem cells (Dayton, Ohio) · 2014Article
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveTongue papillae are critical organs in mastication. There are four different types of tongue papillae; fungiform, circumvallate, foliate, and filiform papillae. Unlike the other three taste papillae, non-gustatory papillae, filiform papillae cover the entire dorsal surface of the tongue and are important structures for the mechanical stress of sucking. Filiform papillae are further classified into two subtypes with different morphologies, depending on their location on the dorsum of the tongue. The filiform papillae at the intermolar eminence have pointed tips, whereas filiform papillae with rounded tips are found in other regions (anterior tongue). It remains unknown how the shape of each type of filiform papillae are determined during their development. Bmp signalling pathway has been known to regulate mechanisms that determine the shapes of many ectodermal organs. The aim of this study was to investigate the role of Bmp signalling in filiform papillae development.
designComparative in situ hybridization analysis of six Bmps (Bmp2-Bmp7) and two Bmpr genes (Bmpr1a and Bmpr1b) were carried out in filiform papillae development. We further examined tongue papillae in mice over-expressing Noggin under the keratin14 promoter (K14-Noggin).
resultsWe identified a dynamic temporo-spatial expression of Bmps in filiform papillae development. The K14-Noggin mice showed pointed filiform papillae in regions of the tongue normally occupied by the rounded type.
conclusionsBmp signalling thus regulates the shape of filiform papillae.
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