ArticleCell cycle (Georgetown, Tex.)2012
Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells.
Article in Cell cycle (Georgetown, Tex.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- PYGO2 regulates IL10 and plays immunosuppressive role through ESCC progression.BMC molecular and cell biology · 2025Article
- Pygo-F773W Mutation Reveals Novel Functions beyond Wnt Signaling inInternational journal of molecular sciences · 2024Article
- Review
- Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2.Cancer science · 2016Article
- Epigenetic regulation of the histone-to-protamine transition during spermiogenesis.Reproduction (Cambridge, England) · 2016Review
- Crosstalk of the Wnt/β-catenin pathway with other pathways in cancer cells.Genes & diseases · 2016Article
- The Commercial Antibodies Widely Used to Measure H3 K56 Acetylation Are Non-Specific in Human and Drosophila Cells.PloS one · 2016Article
- Mutations that prevent or mimic persistent post-translational modifications of the histone H3 globular domain cause lethality and growth defects in Drosophila.Epigenetics & chromatin · 2016Article
- Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation.The Journal of biological chemistry · 2015Article
- Pygo2 siRNA Inhibit the Growth and Increase Apoptosis of U251 Cell by Suppressing Histone H3K4 Trimethylation.Journal of molecular neuroscience : MN · 2015Article
- Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression.Oncotarget · 2015Article
- Cell cycle-dependent changes in H3K56ac in human cells.Cell cycle (Georgetown, Tex.) · 2015Article
- Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Neural crest stem cell-specific deletion of the Pygopus2 gene modulates hair follicle development.Stem cell reviews and reports · 2014Article
- Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice.Oncogene · 2014Article
- Article
- Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells.Cell stem cell · 2013Article
- Article
- The many faces and functions of β-catenin.The EMBO journal · 2012Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Histone gene expression is tightly controlled during cell cycle. The epigenetic mechanisms underlying this regulation remain to be fully elucidated. Pygopus 2 (Pygo2) is a context-dependent co-activator of Wnt/β-catenin signaling and a chromatin effector that participates in histone modification. In this study, we show that Pygo2 is required for the optimal expression of multiple classes of histone genes in cultured human mammary epithelial cells. Using chromatin immunoprecipitation assay, we demonstrate that Pygo2 directly occupies the promoters of multiple histone genes and enhances the acetylation of lysine 56 in histone H3 (H3K56Ac), previously shown to facilitate yeast histone gene transcription at these promoters. Moreover, we report reduced global levels of H3K56Ac in Pygo2-depleted cells that occur in a cell cycle-independent manner. Together, our data uncover a novel regulator of mammalian histone gene expression that may act in part via modifying H3K56Ac.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.