Trial reportVeterinary research2011
Vaccination of influenza a virus decreases transmission rates in pigs.
Trial report in Veterinary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mechanistic Models of Influenza Transmission in Commercial Swine Populations: A Systematic Review.Pathogens (Basel, Switzerland) · 2024Pooled it
- Influenza A virus infection dynamics in two sow herds and effects of interventions.Porcine health management · 2026Article
- Anti-neuraminidase and anti-HA stalk antibodies reduce the susceptibility to and infectivity of influenza A/H3N2 virus.Nature communications · 2025Article
- Disruption of influenza A virus transmission in gene-edited pigs.Emerging microbes & infections · 2025Article
- Influenza mRNA vaccine reduces pathogenicity and transmission of A(H5N1) virus in a ferret model.NPJ vaccines · 2025Article
- Epitope-optimized vaccine elicits enduring immunity against swine influenza A virus.Nature communications · 2025Article
- Article
- Risk of Swine Influenza Virus Spillover at the Human-Swine Interface - a Scoping Review.International journal of public health · 2025Article
- Evaluating preventive measures for the zoonotic transmission of swine influenza A variant at agricultural fairs in the United States: a mathematical modeling study.Frontiers in veterinary science · 2025Article
- Estimating the risk of zoonotic transmission of swine influenza A variant during agricultural fairs in the United States: a mathematical modeling.Frontiers in veterinary science · 2025Article
- Emerging threats of HPAI H5N1 clade 2.3.4.4b in swine: knowledge gaps and the imperative for a One Health approach.Frontiers in veterinary science · 2025Review
- Mathematical modeling for estimating influenza vaccine efficacy: A case study of the Valencian Community, Spain.Infectious Disease Modelling · 2024Article
- The Reproduction Number of Swine Viral Respiratory Diseases: A Systematic Review.Veterinary sciences · 2024Review
- Quantitative measurement of influenza virus transmission in animal model: an overview of current state.Biophysical reviews · 2023Review
- A stochastic compartmental model to simulate intra- and inter-species influenza transmission in an indoor swine farm.PloS one · 2023Article
- Evaluation of internal farm biosecurity measures combined with sow vaccination to prevent influenza A virus infection in groups of due-to-wean pigs.BMC veterinary research · 2022Article
- Farm management practices, biosecurity and influenza a virus detection in swine farms: a comprehensive study in colombia.Porcine health management · 2022Article
- Article
- Alternating 3 different influenza vaccines for swine in Europe for a broader antibody response and protection.Veterinary research · 2022Article
- Immunocyte Populations Observed from Birth to Weaning in Blood, Spleen and Mesenteric Lymph Nodes of Piglets.Animals : an open access journal from MDPI · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Limited information is available on the transmission and spread of influenza virus in pig populations with differing immune statuses. In this study we assessed differences in transmission patterns and quantified the spread of a triple reassortant H1N1 influenza virus in naïve and vaccinated pig populations by estimating the reproduction ratio (R) of infection (i.e. the number of secondary infections caused by an infectious individual) using a deterministic Susceptible-Infectious-Recovered (SIR) model, fitted on experimental data. One hundred and ten pigs were distributed in ten isolated rooms as follows: (i) non-vaccinated (NV), (ii) vaccinated with a heterologous vaccine (HE), and (iii) vaccinated with a homologous inactivated vaccine (HO). The study was run with multiple replicates and for each replicate, an infected non-vaccinated pig was placed with 10 contact pigs for two weeks and transmission of influenza evaluated daily by analyzing individual nasal swabs by RT-PCR. A statistically significant difference between R estimates was observed between vaccinated and non-vaccinated pigs (p < 0.05). A statistically significant reduction in transmission was observed in the vaccinated groups where R (95%CI) was 1 (0.39-2.09) and 0 for the HE and the HO groups respectively, compared to an Ro value of 10.66 (6.57-16.46) in NV pigs (p < 0.05). Transmission in the HE group was delayed and variable when compared to the NV group and transmission could not be detected in the HO group. Results from this study indicate that influenza vaccines can be used to decrease susceptibility to influenza infection and decrease influenza transmission.
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