ArticleBMC evolutionary biology2011
Leucine-rich repeat receptor kinases are sporadically distributed in eukaryotic genomes.
Article in BMC evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Oomycete plant pathogens: biology, pathogenesis and emerging control strategies.Nature reviews. Microbiology · 2026Review
- The apoplastic protein OsCPIP8 confers dual protection by inhibiting pathogenic protease and activating rice immunity.Nature communications · 2025Article
- The Past, Present, and Future of Plant Activators Targeting the Salicylic Acid Signaling Pathway.Genes · 2024Review
- PcLRR-RK3, an LRR receptor kinase is required for growth andMycology · 2024Article
- Life and death: the destiny of Phytophthora sojae determined by a receptor-like kinase.Stress biology · 2023Article
- Genome-wide analysis and characterization of the LRR-RLK gene family provides insights into anthracnose resistance in common bean.Scientific reports · 2023Article
- A Phytophthora receptor-like kinase regulates oospore development and can activate pattern-triggered plant immunity.Nature communications · 2023Article
- An LTR retrotransposon insertion inside CsERECTA for an LRR receptor-like serine/threonine-protein kinase results in compact (cp) plant architecture in cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Cross-kingdom analyses of transmembrane protein kinases show their functional diversity and distinct origins in protists.Computational and structural biotechnology journal · 2023Article
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- Identification and characterization of the LRR repeats in plant LRR-RLKs.BMC molecular and cell biology · 2021Article
- Genome-Wide Identification and Evolution of Receptor-Like Kinases (RLKs) and Receptor like Proteins (RLPs) inBiology · 2020Article
- The origin and evolution of cell-intrinsic antibacterial defenses in eukaryotes.Current opinion in genetics & development · 2019Review
- Investigation of evolutionary and expressional relationships in the function of the leucine-rich repeat receptor-like protein kinase gene family (LRR-RLK) in the radish (Raphanus sativus L.).Scientific reports · 2019Article
- Commentary: Leucine-rich Repeat Receptor-Like Gene Screen Reveals thatFrontiers in genetics · 2019Article
- Leucine-rich repeat receptor-like gene screen reveals that Nicotiana RXEG1 regulates glycoside hydrolase 12 MAMP detection.Nature communications · 2018Article
- Origin and diversification of leucine-rich repeat receptor-like protein kinase (LRR-RLK) genes in plants.BMC evolutionary biology · 2017Article
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- LRR-RLK family from two Citrus species: genome-wide identification and evolutionary aspects.BMC genomics · 2016Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlant leucine-rich repeat receptor-like kinases (LRR-RLKs) are receptor kinases that contain LRRs in their extracellular domain. In the last 15 years, many research groups have demonstrated major roles played by LRR-RLKs in plants during almost all developmental processes throughout the life of the plant and in defense/resistance against a large range of pathogens. Recently, a breakthrough has been made in this field that challenges the dogma of the specificity of plant LRR-RLKs.
resultsWe analyzed ~1000 complete genomes and show that LRR-RK genes have now been identified in 8 non-plant genomes. We performed an exhaustive phylogenetic analysis of all of these receptors, revealing that all of the LRR-containing receptor subfamilies form lineage-specific clades. Our results suggest that the association of LRRs with RKs appeared independently at least four times in eukaryotic evolutionary history. Moreover, the molecular evolutionary history of the LRR-RKs found in oomycetes is reminiscent of the pattern observed in plants: expansion with amplification/deletion and evolution of the domain organization leading to the functional diversification of members of the gene family. Finally, the expression data suggest that oomycete LRR-RKs may play a role in several stages of the oomycete life cycle.
conclusionsIn view of the key roles that LRR-RLKs play throughout the entire lifetime of plants and plant-environment interactions, the emergence and expansion of this type of receptor in several phyla along the evolution of eukaryotes, and particularly in oomycete genomes, questions their intrinsic functions in mimicry and/or in the coevolution of receptors between hosts and pathogens.
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