ArticleDisease models & mechanisms2012
A rodent model of rapid-onset diabetes induced by glucocorticoids and high-fat feeding.
Article in Disease models & mechanisms, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Individual differences in glucocorticoid regulation: Does it relate to disease risk and resilience?Frontiers in neuroendocrinology · 2020Pooled it
- Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats.Animal models and experimental medicine · 2026Article
- Endotoxin-induced inflammation promotes, via the adrenomedullary system, a hyperglycemic and anti-inflammatory reflex.Brain, behavior, & immunity - health · 2026Article
- PPARα suppresses low-intensity-noise-induced body weight gain in mice: the activated HPA axis plays an critical role.International journal of obesity (2005) · 2024Article
- Liraglutide provides cardioprotection through the recovery of mitochondrial dysfunction and oxidative stress in aging hearts.Journal of physiology and biochemistry · 2023Article
- Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease.International journal of molecular sciences · 2022Review
- Clinical and Anatomopathological Evaluation of BALB/c Murine Models Infected with Isolates of Seven PathogenicPathogens (Basel, Switzerland) · 2021Article
- Chronic glucocorticoid treatment induces hepatic lipid accumulation and hyperinsulinaemia in part through actions on AgRP neurons.Scientific reports · 2021Article
- Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.Nature metabolism · 2021Article
- From Obesity to Hippocampal Neurodegeneration: Pathogenesis and Non-Pharmacological Interventions.International journal of molecular sciences · 2020Review
- Current perspectives of oleic acid: Regulation of molecular pathways in mitochondrial and endothelial functioning against insulin resistance and diabetes.Reviews in endocrine & metabolic disorders · 2020Review
- Article
- Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat Diet in Mice.International journal of molecular sciences · 2020Article
- Air Pollution, Stress, and Allostatic Load: Linking Systemic and Central Nervous System Impacts.Journal of Alzheimer's disease : JAD · 2019Review
- Glucocorticoid-Induced Metabolic Disturbances Are Exacerbated in Obese Male Mice.Endocrinology · 2018Article
- The Extending Spectrum of NPC1-Related Human Disorders: From Niemann-Pick C1 Disease to Obesity.Endocrine reviews · 2018Review
- Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid.Endocrinology · 2018Article
- Effects of conjugated linoleic acid/n-3 and resistance training on muscle quality and expression of atrophy-related ubiquitin ligases in middle-aged mice with high-fat diet-induced obesity.Journal of exercise nutrition & biochemistry · 2017Article
- Transendothelial movement of adiponectin is restricted by glucocorticoids.The Journal of endocrinology · 2017Article
- Nuclear Receptor Function through Genomics: Lessons from the Glucocorticoid Receptor.Trends in endocrinology and metabolism: TEM · 2017Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucocorticoids (GCs) are potent pharmacological agents used to treat a number of immune conditions. GCs are also naturally occurring steroid hormones (e.g. cortisol, corticosterone) produced in response to stressful conditions that are thought to increase the preference for calorie dense 'comfort' foods. If chronically elevated, GCs can contribute to the development of type 2 diabetes mellitus (T2DM), although the mechanisms for the diabetogenic effects are not entirely clear. The present study proposes a new rodent model to investigate the combined metabolic effects of elevated GCs and high-fat feeding on ectopic fat deposition and diabetes development. Male Sprague-Dawley rats (aged 7-8 weeks) received exogenous corticosterone or wax (placebo) pellets, implanted subcutaneously, and were fed either a standard chow diet (SD) or a 60% high-fat diet (HFD) for 16 days. Animals given corticosterone and a HFD (cort-HFD) had lower body weight and smaller relative glycolytic muscle mass, but increased relative epididymal mass, compared with controls (placebo-SD). Cort-HFD rats exhibited severe hepatic steatosis and increased muscle lipid deposition compared with placebo-SD animals. Moreover, cort-HFD animals were found to exhibit severe fasting hyperglycemia (60% increase), hyperinsulinemia (80% increase), insulin resistance (60% increase) and impaired β-cell response to oral glucose load (20% decrease) compared with placebo-SD animals. Thus, a metabolic syndrome or T2DM phenotype can be rapidly induced in young Sprague-Dawley rats by using exogenous GCs if a HFD is consumed. This finding might be valuable in examining the physiological and molecular mechanisms of GC-induced metabolic disease.
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