ArticleProceedings of the National Academy of Sciences of the United States of America2012
Label-free Raman observation of cytochrome c dynamics during apoptosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers.
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Who cites it
166 citing papers in PubMed.
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- All-optical multimodal mapping of single-cell-type-specific metabolic activities via REDCAT.Nature methods · 2026Article
- Label-Free Hyperspectral Raman Imaging and Analysis of a 3D Spheroid Model for Liver Fibrosis Study.Chemical & biomedical imaging · 2026Article
- Broadband electronic resonance coherent anti-Stokes/Stokes Raman scattering microscopy.Science advances · 2026Article
- Label-Free Detection of Cellular Aβ Accumulation and Mitochondrial Dysfunction in AD Cell Models via Raman Microscopy.Analytical chemistry · 2026Article
- Illuminating aging with multimodal optical metabolic imaging.Science advances · 2026Review
- The Next Frontier in Vibrational Imaging: Chemically Designed Raman Probes Pass the Spectral Barrier.JACS Au · 2026Review
- Automated High-Throughput Raman Spectral Framework for Cellular Differentiation Monitoring.Nano letters · 2026Article
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- Spectral discrimination of pediatric SF188 and adult glioblastoma stem cells by deep learning-enhanced Raman profiling.Frontiers in oncology · 2026Article
- Deciphering macrophage molecular responses toFrontiers in microbiology · 2026Article
- High-throughput spontaneous Raman imaging of biological specimens with water background reduction.Biomedical optics express · 2026Article
- Single-cell Raman profiling of B cell differentiation and leukemic transformation with transcriptome inference.Frontiers in immunology · 2026Article
- Stimulated Raman Scattering Imaging Enabled Biomarker Discovery for Precision Medicine.Chemical & biomedical imaging · 2025Review
- Rapid culture-free diagnosis of clinical pathogens via integrated microfluidic-Raman micro-spectroscopy.Nature communications · 2025Article
- Integrating spatial and chemical information enhances differentiation of non-alcoholic steatohepatitis states in Raman imaging.Scientific reports · 2025Article
- Raman Monitoring ofInternational journal of molecular sciences · 2025Article
106 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed label-free observation of molecular dynamics in apoptotic cells by Raman microscopy. Dynamic changes in cytochrome c distribution at the Raman band of 750 cm(-1) were observed after adding an apoptosis inducer to the cells. The comparison of mitochondria fluorescence images and Raman images of cytochrome c confirmed that changes in cytochrome c distribution can be distinguished as release of cytochrome c from mitochondria. Our observation also revealed that the redox state of cytochrome c was maintained during the release from the mitochondria. Monitoring mitochondrial membrane potential with JC-1 dye confirmed that the observed cytochrome c release was associated with apoptosis.
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