ArticleMolecular and cellular biology2012
Phosphorylation of the transcription factor YY1 by CK2α prevents cleavage by caspase 7 during apoptosis.
Article in Molecular and cellular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- FGF4 initiates X-chromosome inactivation via activating YY1 and prompting loss of pluripotency factors.The EMBO journal · 2026Article
- Yin Yang 1: Function, Mechanisms, and Glia.Neurochemical research · 2025Review
- A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice.Journal of experimental & clinical cancer research : CR · 2024Article
- Article
- Role of YY1 in the Regulation of Anti-Apoptotic Gene Products in Drug-Resistant Cancer Cells.Cancers · 2023Review
- Toward a hypothesis-free understanding of how phosphorylation dynamically impacts protein turnover.Proteomics · 2023Article
- CK2 and the Hallmarks of Cancer.Biomedicines · 2022Review
- Manganese phosphorylates Yin Yang 1 at serine residues to repress EAAT2 in human H4 astrocytes.Toxicology letters · 2022Article
- A Systematic Pan-Cancer Analysis of YY1 Aberrations and their Relationship with Clinical Outcome, Tumor Microenvironment, and Therapeutic Targets.Journal of immunology research · 2022Article
- Synthesis of Novel Halogenated Heterocycles Based onMolecules (Basel, Switzerland) · 2021Article
- Global and Site-Specific Effect of Phosphorylation on Protein Turnover.Developmental cell · 2021Article
- Aurora A Phosphorylation of YY1 during Mitosis Inactivates its DNA Binding Activity.Scientific reports · 2017Article
- YY1 Is Required for Posttranscriptional Stability of SOX2 and OCT4 Proteins.Cellular reprogramming · 2017Article
- Methylation of transcription factor YY2 regulates its transcriptional activity and cell proliferation.Cell discovery · 2017Article
- A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response.Frontiers in plant science · 2017Article
- Regulation of Transcription Factor Yin Yang 1 by SET7/9-mediated Lysine Methylation.Scientific reports · 2016Article
- Stability of structured Kaposi's sarcoma-associated herpesvirus ORF57 protein is regulated by protein phosphorylation and homodimerization.Journal of virology · 2015Article
- Proteomic profile of pre - B2 lymphoblasts from children with acute lymphoblastic leukemia (ALL) in relation with the translocation (12; 21).Clinical proteomics · 2014Article
- Review
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this report, we describe the phosphorylation of Yin Yang 1 (YY1) in vitro and in vivo by CK2α (casein kinase II), a multifunctional serine/threonine protein kinase. YY1 is a ubiquitously expressed multifunctional zinc finger transcription factor implicated in regulation of many cellular and viral genes. The products of these genes are associated with cell growth, the cell cycle, development, and differentiation. Numerous studies have linked YY1 to tumorigenesis and apoptosis. YY1 is a target for cleavage by caspases in vitro and in vivo as well, but very little is known about the mechanisms that regulate its cleavage during apoptosis. Here, we identify serine 118 in the transactivation domain of YY1 as the site of CK2α phosphorylation, proximal to a caspase 7 cleavage site. CK2α inhibitors, as well as knockdown of CK2α by small interfering RNA, reduce S118 phosphorylation in vivo and enhance YY1 cleavage under apoptotic conditions, whereas increased CK2α activity by overexpression in vivo elevates S118 phosphorylation. A serine-to-alanine substitution at serine 118 also increases the cleavage of YY1 during apoptosis compared to wild-type YY1. Taken together, we have discovered a regulatory link between YY1 phosphorylation at serine 118 and regulation of its cleavage during programmed cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.