Evidence map›Paper›PMID 22183840›Full record

Trial reportSexually transmitted diseases2012

Clinical and virologic response to episodic acyclovir for genital ulcers among HIV-1 seronegative, herpes simplex virus type 2 seropositive African women: a randomized, placebo-controlled trial.

Jared M Baeten, Stewart E Reid, Sinead Delany-Moretlwe, James P Hughes, Richard S Wang, Ellen Wilcox, Mohammed Limbada, Godspower Akpomiemie, Lawrence Corey, Anna Wald and 1 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sexually transmitted diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00808405 (Prospective Study of Pharmacokinetics, Clinical and Virologic Response to Acyclovir Episodic Therapy for Genital Herpes Ulcers in HIV Negative African Women), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00808405 nacompletednot on this map

Prospective Study of Pharmacokinetics, Clinical and Virologic Response to Acyclovir Episodic Therapy for Genital Herpes Ulcers in HIV Negative African Women

TypeinterventionalSponsorUniversity of WashingtonRan2009 to 2010Enrolled88ConditionsGenital HerpesArmsacyclovir, matching placebo
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Jared M BaetenDepartment of Global Health, University of Washington, Seattle, WA 98104, USA. jbaeten@uw.edu
Stewart E Reid
Sinead Delany-Moretlwe
James P Hughes
Richard S Wang
Ellen Wilcox
Mohammed Limbada
Godspower Akpomiemie
Lawrence Corey
Anna Wald
Connie Celum
University of the Witwatersrand · ZACancer Research Center · USCentre for Infectious Disease Research in Zambia · ZMFred Hutch Cancer Center · USUniversity of Alabama at Birmingham · US

Funding

HIV PREVENTION TRIALS NETWORK LEADERSHIP GROUPU01AI046749 · NIAID · FAMILY HEALTH INTERNATIONAL · PI CATES, WILLARD · 1999 to 2005
$73.5M
THE PERINATAL COMPLICATIONS OF ASYMPTOMATIC GENITAL HERPES SIMPLEX VIRUSP01AI030731 · NIAID · UNIVERSITY OF WASHINGTON · PI ZHU, JIA · 1991 to 2017
$34.3M
Acyclovir to Prevent HIV Acquisition in HSV-2+ PersonsU01AI052054 · NIAID · UNIVERSITY OF WASHINGTON · PI CELUM, CONNIE L · 2005 to 2007
$13.6M
NIAID NIH HHS P01 AI030731NIAID NIH HHS P01 AI30731NIAID NIH HHS U01 AI046749NIAID NIH HHS U01 AI052054NIAID NIH HHS U01 AI46749NIAID NIH HHS U01 AI52054
6 · The paper itself

Abstract

In a randomized trial among African women with recurrent genital herpes, episodic acyclovir therapy resulted in modestly greater likelihood of lesion healing (hazard ratio [HR] = 1.48, P = 0.098; mean, 5.1 vs. 6.0 days) and cessation of herpes simplex virus shedding (HR = 1.88, P = 0.008; mean, 3.0 vs. 5.0 days) compared with placebo, similar to results of studies in high-income countries (ClinicalTrials.gov registration NCT00808405).

Indexed as

AcyclovirAdultAntiviral AgentsDNA, ViralDouble-Blind MethodFemaleHerpes GenitalisHerpesvirus 2, HumanHIV-1HIV SeronegativityHumansKaplan-Meier EstimateMiddle AgedRecurrenceSeroepidemiologic StudiesSouth AfricaAcyclovirAntiviral AgentsDNA, Viral

Identifiers

PMID22183840
PMCPMC3244838
OpenAlexW2325373262

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.