ArticleMagnetic resonance in medicine2012
Pharmacological MRI of the choroid and retina: blood flow and BOLD responses during nitroprusside infusion.
Article in Magnetic resonance in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Neuromodulation in Small Animal fMRI.Journal of magnetic resonance imaging : JMRI · 2025Review
- Distinct neurochemical influences on fMRI response polarity in the striatum.Nature communications · 2024Article
- Spectral fiber photometry derives hemoglobin concentration changes for accurate measurement of fluorescent sensor activity.Cell reports methods · 2022Article
- Computing hemodynamic response functions from concurrent spectral fiber-photometry and fMRI data.Neurophotonics · 2022Article
- An isotropic EPI database and analytical pipelines for rat brain resting-state fMRI.NeuroImage · 2021Article
- Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization.Frontiers in neuroinformatics · 2019Review
- Adolescent alcohol exposure decreases frontostriatal resting-state functional connectivity in adulthood.Addiction biology · 2018Article
- Functional circuit mapping of striatal output nuclei using simultaneous deep brain stimulation and fMRI.NeuroImage · 2017Article
- Resting state network topology of the ferret brain.NeuroImage · 2016Article
- Functional Magnetic Resonance Imaging of Electrical and Optogenetic Deep Brain Stimulation at the Rat Nucleus Accumbens.Scientific reports · 2016Article
- Dynamic perfusion and diffusion MRI of cortical spreading depolarization in photothrombotic ischemia.Neurobiology of disease · 2014Article
- Comparison of retinal and cerebral blood flow between continuous arterial spin labeling MRI and fluorescent microsphere techniques.Journal of magnetic resonance imaging : JMRI · 2014Article
- Magnetic resonance imaging of the retina: from mice to men.Magnetic resonance in medicine · 2014Review
- Postocclusive reactive hyperemia occurs in the rat retinal circulation but not in the choroid.Investigative ophthalmology & visual science · 2013Article
- MRI study of cerebral, retinal and choroidal blood flow responses to acute hypertension.Experimental eye research · 2013Article
- Ultra high-resolution fMRI and electrophysiology of the rat primary somatosensory cortex.NeuroImage · 2013Article
- Quantitative retinal and choroidal blood flow during light, dark adaptation and flicker light stimulation in rats using fluorescent microspheres.Current eye research · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Nitroprusside, a vasodilatory nitric oxide donor, is clinically used during vascular surgery and to lower blood pressure in acute hypertension. This article reports a novel application of blood flow (BF) and blood oxygenation level dependent (BOLD) MRI on an 11.7T scanner to image the rat chorioretinal BF and BOLD changes associated with graded nitroprusside infusion. At low doses (1 or 2 μg/kg/min), nitroprusside increased BF as expected but decreased BOLD signals, showing an intriguing BF-BOLD uncoupling. At high doses (3-5 μg/kg/min), nitroprusside decreased BF and markedly decreased BOLD signals. To our knowledge, this is the first pharmacological MRI application of the retina. This approach has potential to open up new avenues to study the drug-related hemodynamic functions and to evaluate the effects of novel therapeutic interventions on BOLD and BF in the normal and diseased retinas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.