ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2012
MicroRNA-200 is commonly repressed in conjunctival MALT lymphoma, and targets cyclin E2.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Role of miRNA in adult ocular tumorigenesis.Frontiers in molecular biosciences · 2025Review
- Cell-Based Therapies for Glaucoma.Translational vision science & technology · 2023Article
- MicroRNA and Their Potential Role in Conjunctival Disorders.Korean journal of ophthalmology : KJO · 2022Review
- Effect of miR-184 and miR-205 on the tumorigenesis of conjunctival mucosa associated lymphoid tissue lymphoma through regulating RasL10B and TNFAIP8.International journal of ophthalmology · 2022Article
- Recent Advances in the Genetic of MALT Lymphomas.Cancers · 2021Review
- Single-fraction low-energy electronic brachytherapy for conjunctival lymphoma.Journal of contemporary brachytherapy · 2020Article
- Association between occupational exposure to trichloroethylene and serum levels of microRNAs: a cross-sectional molecular epidemiology study in China.International archives of occupational and environmental health · 2019Article
- EGBMMDA: Extreme Gradient Boosting Machine for MiRNA-Disease Association prediction.Cell death & disease · 2018Article
- DRMDA: deep representations-based miRNA-disease association prediction.Journal of cellular and molecular medicine · 2018Article
- p53-dependent up-regulation of CDKN1A and down-regulation of CCNE2 in response to beryllium.Cell proliferation · 2016Article
- CD46 Activation Regulates miR-150-Mediated Control of GLUT1 Expression and Cytokine Secretion in Human CD4+ T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Correlation between the overexpression of Yin Yang 1 and the expression levels of miRNAs in Burkitt's lymphoma: A computational study.Oncology letters · 2016Article
- miR-155 as a Biomarker in B-Cell Malignancies.BioMed research international · 2016Review
- Tumour-suppressive microRNA-144-5p directly targets CCNE1/2 as potential prognostic markers in bladder cancer.British journal of cancer · 2015Article
- The role of miR-150 in normal and malignant hematopoiesis.Oncogene · 2014Review
- MicroRNAs in Acute Myeloid Leukemia and Other Blood Disorders.Leukemia research and treatment · 2012Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAberrant microRNA expression is implicated in cancer initiation and progression. We sought to identify dysregulated miRNAs in conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma, and investigated their biological significance.
methodsThe profiles of miRNAs in conjunctival MALT lymphoma and normal adjacent tissues were investigated by microRNA microarray of four pairs of surgically removed conjunctival MALT lymphoma tissues and matched controls. The results of microarray were further confirmed in 14 paired conjunctival MALT lymphoma samples (including the former four pairs) using quantitative RT-PCR. The functional effect of miR-200 was examined further. A luciferase reporter assay was performed to confirm the predicted target.
resultsThe microarray results revealed upregulated miR-150/155, and downregulated miR-184, miR-200a, b, c, and miR-205. These findings were confirmed by quantitative RT-PCR. Targetscan analysis suggested cyclin E2 as potential target of miR-200a, b, c. Luciferase reporter assay using vectors containing the 3'UTR of cyclin E2 showed that miR-200a, b, c could suppress luciferase activities. RT-PCR and immunoblotting studies revealed that overexpression of miR-200a, b, c reduced the mRNA and protein levels of cyclin E2 respectively.
conclusionsWe demonstrated that miRNAs were dysregulated in conjunctival MALT lymphoma, and dysregulation of the miR-200 family could be involved in the pathogenesis and progression of the disease.
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