ReviewNature reviews. Rheumatology2011
The spectrum of CNS vasculitis in children and adults.
Review in Nature reviews. Rheumatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 71 citations in OpenAlex.
- Towards a histological diagnosis of childhood small vessel CNS vasculitis.Pediatric rheumatology online journal · 2024Article
- Neuroimaging Scoring Tools to Differentiate Inflammatory Central Nervous System Small-Vessel Vasculitis: A Need for Artificial Intelligence/Machine Learning?-A Scoping Review.Tomography (Ann Arbor, Mich.) · 2023Article
- Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE).Molecular and cellular pediatrics · 2023Review
- Childhood Cerebral Vasculitis : A Multidisciplinary Approach.Clinical neuroradiology · 2023Review
- Utility of high-resolution magnetic resonance vessel wall imaging in differentiating between atherosclerotic plaques, vasculitis, and arterial dissection.Neuroradiology · 2023Article
- Human Leukocyte Antigen (HLA) Modulates the Dependence on Age of the Variability of Synchronous Neural Interactions.Neuroscience insights · 2023Article
- Case Report: Interest of Positron Emission Tomography in Pediatric Small Vessel Primary Angiitis of the Central Nervous System.Frontiers in pediatrics · 2022Article
- Arteriopathy in pediatric stroke: an underestimated clinical entity.Arquivos de neuro-psiquiatria · 2021Review
- Diagnosis and Treatment of Angiography Positive Medium to Large Vessel Childhood Primary Angiitis of Central Nervous System (p-cPACNS): An International Survey.Frontiers in pediatrics · 2021Article
- Diagnosis and Treatment of Small Vessel Childhood Primary Angiitis of the Central Nervous System (sv-cPACNS): An International Survey.Frontiers in pediatrics · 2021Article
- Tumefactive Primary Central Nervous System Vasculitis: Imaging Findings of a Rare and Underrecognized Neuroinflammatory Disease.AJNR. American journal of neuroradiology · 2020Article
- Clinical Perspective on Primary Angiitis of the Central Nervous System in Childhood (cPACNS).Frontiers in pediatrics · 2020Review
- Strategies for treatment of childhood primary angiitis of the central nervous system.Neurology(R) neuroimmunology & neuroinflammation · 2019Review
- Health-related quality of life in children with inflammatory brain disease.Pediatric rheumatology online journal · 2018Observational
- A Closer Look at Angiitis of the central nervous system.Neurosciences (Riyadh, Saudi Arabia) · 2017Article
- Role of magnetic resonance imaging in the diagnosis of primary central nervous system angiitis.Experimental and therapeutic medicine · 2017Article
- The growing spectrum of antibody-associated inflammatory brain diseases in children.Neurology(R) neuroimmunology & neuroinflammation · 2015Article
- Cerebral vasculitis in adults: what are the steps in order to establish the diagnosis? Red flags and pitfalls.Clinical and experimental immunology · 2014Review
- Advances in primary angiitis of the central nervous system.Current cardiology reports · 2014Review
- Angiogenesis in steno-occlusive vasculopathies as a common pathway for intracranial haemorrhage. A report of six cases.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciencesArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children and adults who present with severe, newly acquired neurological or psychiatric deficits should be evaluated for an underlying inflammatory brain disease-the inflammation could be reversible, if diagnosed and treated rapidly. In our experience, primary angiitis of the central nervous system (PACNS) is the most common inflammatory brain disease and is increasingly recognized across patients of all ages. Distinct disease subtypes have been reported with characteristic disease courses, neuroimaging features and histopathological findings. In this Review, we provide a comprehensive comparison of childhood and adult PACNS, revealing distinct gender distributions, characteristic presenting clinical phenotypes and tailored differential diagnosis evaluations in the different subtypes of PACNS. Novel and traditional laboratory markers can help to define disease subtype and activity, whilst MRI and angiography can aid diagnosis in both children and adults. Characteristic patterns of parenchymal lesions and vessel involvement have been identified in PACNS and differ markedly between subtypes. Brain histopathology has also revealed distinct inflammatory pathways at different ages. Immunosuppressive treatment protocols have been shown to be effective and safe across the age spectrum; overall, in the past few years, the mortality of PACNS has decreased dramatically.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.