Evidence map›Paper›PMID 22183559›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2012

Molecular-level simulation of pandemic influenza glycoproteins.

Rommie E Amaro, Wilfred W Li

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rommie E AmaroDepartment of Pharmaceutical Sciences, University of California, Irvine, CA, USA. ramaro@uci.edu
Wilfred W Li

Funding

VISUALIZATION TOOLS FOR AUTOMATED MOLECULAR MICROSCOPYP41RR008605 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAPADOPOULOS, PHILIP · 1994 to 2011
$28.1M
A Structural Systems Biology Approach to Drug DiscoveryDP2OD007237 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AMARO, ROMMIE E · 2010 to 2015
$2.9M
Towards a Structural Systems Biology Approach for Anti-Trypanosomal TherapeuticsK22AI081901 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AMARO, ROMMIE E · 2010 to 2011
$270k
NCRR NIH HHS P41 RR008605NCRR NIH HHS P41 RR08605NIAID NIH HHS 1-K22-AI081901NIAID NIH HHS K22 AI081901NIH HHS 1-DP2-OD007237NIH HHS DP2 OD007237
6 · The paper itself

Abstract

Computational simulation of pandemic diseases provides important insight into many disease features that may benefit public health. This is especially true for the influenza virus, a continuing global pandemic threat. Molecular or atomic-level investigation of influenza has predominantly focused on the two major virus glycoproteins, neuraminidase (NA) and hemagglutinin (HA). In this chapter, we walk the readers through major considerations for studying pandemic influenza glycoproteins, from choosing the most useful choice of system(s) to avoiding common pitfalls in experimental design and execution. While a brief discussion of several potential simulation and docking techniques is presented, we emphasize molecular dynamics (MD) and Brownian dynamics (BD) simulation techniques and molecular docking, within the context of biologically outstanding questions in influenza research.

Indexed as

Molecular Dynamics SimulationPandemicsHemagglutinin Glycoproteins, Influenza VirusHumansInfluenza, HumanNeuraminidaseHemagglutinin Glycoproteins, Influenza VirusNeuraminidase

Identifiers

PMID22183559
PMCPMC3352029

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.