SynthesisMolecular biology reports2012
The association between the mannose-binding lectin codon 54 polymorphism and systemic lupus erythematosus: a meta-analysis update.
Synthesis in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Mannose-binding lectin gene polymorphism in psoriasis and vitiligo: an observational study and computational analysis.Frontiers in medicine · 2023Article
- Thrombotic microangiopathy mediates poor prognosis among lupus nephritisFrontiers in immunology · 2022Article
- Understanding the genetics of systemic lupus erythematosus using Bayesian statistics and gene network analysis.Clinical and experimental pediatrics · 2021Article
- Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus.Clinical and experimental immunology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine whether the functional mannose-binding lectin (MBL2) exon 1 codon 54 polymorphism (rs1800450) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the MBL2 codon 54 polymorphism across 21 comparative studies. Meta-analysis showed an association between the MBL2 codon 54 B allele and SLE in all study subjects [odds ratio (OR) = 1.298, 95% confidence interval (CI) = 1.154-1.459, P = 1.4 × 10(-5)]. Analysis after stratification by ethnicity indicated that the MBL2 codon 54 B allele is significantly associated with SLE in Europeans, Asian, and Africans (OR = 1.246, 95% CI = 1.062-1.462, P = 0.007; OR = 1.268, 95% CI = 1.049-1.532, P = 0.014; OR = 1.939, 95% CI = 1.269-2.962, P = 0.002, respectively). However, African Americans had a much lower prevalence of the T allele (5.8%) than any other populations studied, whereas Asians had the highest prevalence (16.2%). This meta-analysis confirms that the MBL2 codon 54 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
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