ArticleAntimicrobial agents and chemotherapy2012
Impaired fitness and transmission of macrolide-resistant Campylobacter jejuni in its natural host.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Combating Campylobacter Resistance in Moroccan Poultry Using Essential Oil-Ciprofloxacin Combination.Veterinary medicine and science · 2026Article
- High prevalence of antibiotic resistant Campylobacter among patients attending clinical settings in Kigali, Rwanda.BMC infectious diseases · 2025Article
- The point mutation A1387G in the 16S rRNA gene confers aminoglycoside resistance inAntimicrobial agents and chemotherapy · 2024Article
- From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic Resistance.Annual review of microbiology · 2024Review
- Identification of knowledge gaps in whole-genome sequence analysis of multi-resistant thermotolerant Campylobacter spp.BMC genomics · 2024Article
- Multiplex Real-Time PCR for the Detection of Tetracycline, Ciprofloxacin, and Erythromycin Resistance Determinants from Human and FoodborneMicroorganisms · 2023Article
- Monitoring within-farm transmission dynamics of antimicrobial-resistant Campylobacter in dairy cattle using broth microdilution and long-read whole genome sequencing.Scientific reports · 2023Article
- Genomic Characterization of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Antimicrobial Resistance Profiles, Virulence Genes, and Genetic Diversity of ThermophilicFrontiers in microbiology · 2021Article
- Natural Competence and Horizontal Gene Transfer in Campylobacter.Current topics in microbiology and immunology · 2021Article
- The Acute Host-Response of Turkeys Colonized WithFrontiers in veterinary science · 2021Article
- Core Genome Multilocus Sequence Typing for Food Animal Source Attribution of HumanPathogens (Basel, Switzerland) · 2020Article
- Antimicrobial Resistance Determinants Circulating among ThermophilicAntibiotics (Basel, Switzerland) · 2020Article
- Effect of Macrolide and Rifampin Resistance on the Fitness of Rhodococcus equi.Applied and environmental microbiology · 2019Article
- Genetic Basis and Clonal Population Structure of Antibiotic Resistance inFrontiers in microbiology · 2018Article
- Article
- The Current State of Macrolide Resistance in Campylobacter spp.: Trends and Impacts of Resistance Mechanisms.Applied and environmental microbiology · 2017Review
- Antibacterial Activity of 2-(3',5'-Dibromo-2'-methoxyphenoxy)-3,5- dibromophenol Isolated from Phyllospongia papyracea.Natural product communications · 2017Article
- Virulence and Antimicrobial Resistance inScientifica · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Campylobacter jejuni is a major zoonotic pathogen transmitted to humans via the food chain and is prevalent in chickens, a natural reservoir for this pathogenic organism. Due to the importance of macrolide antibiotics in clinical therapy of human campylobacteriosis, development of macrolide resistance in Campylobacter has become a concern for public health. To facilitate the control of macrolide-resistant Campylobacter, it is necessary to understand if macrolide resistance affects the fitness and transmission of Campylobacter in its natural host. In this study we conducted pairwise competitions and comingling experiments in chickens using clonally related and isogenic C. jejuni strains, which are either susceptible or resistant to erythromycin (Ery). In every competition pair, Ery-resistant (Ery(r)) Campylobacter was consistently outcompeted by the Ery-susceptible (Ery(s)) strain. In the comingling experiments, Ery(r) Campylobacter failed to transmit to chickens precolonized by Ery(s) Campylobacter, while isogenic Ery(s) Campylobacter was able to transmit to and establish dominance in chickens precolonized by Ery(r) Campylobacter. The fitness disadvantage was linked to the resistance-conferring mutations in the 23S rRNA. These findings clearly indicate that acquisition of macrolide resistance impairs the fitness and transmission of Campylobacter in chickens, suggesting that the prevalence of macrolide-resistant C. jejuni will likely decrease in the absence of antibiotic selection pressure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.