Trial reportLangenbeck's archives of surgery2012
Evaluation of the safety and efficacy of MonoMax® suture material for abdominal wall closure after primary midline laparotomy-a controlled prospective multicentre trial: ISSAAC [NCT005725079].
Trial report in Langenbeck's archives of surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Historically-controlled Single-arm Multi-center Prospective Trial to Evaluate the Safety and Efficacy of Aesculap MonoMax® Suture Material for Abdominal Wall Closure After Primary Median Laparotomy
A Multicentre, International, Prospective Post-market Clinical Follow-up to Evaluate MonoMax for Abdominal Wall Closure
Short Stitch Versus Long Stitch Suture Technique Using Monomax® for Abdominal Wall Closure After Primary Median Laparotomy. A Randomized, Controlled, Double-blinded, Multicenter, International Trial
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Small bites versus large bites during fascial closure of midline laparotomies: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2024Pooled it
- Suture choice to reduce occurrence of surgical site infection, hernia, wound dehiscence and sinus/fistula: a network meta-analysis.Annals of the Royal College of Surgeons of England · 2019Pooled it
- Systematic Review and Meta-Regression of Factors Affecting Midline Incisional Hernia Rates: Analysis of 14,618 Patients.PloS one · 2015Pooled it
- Peritoneal closure versus no peritoneal closure for patients undergoing non-obstetric abdominal operations.The Cochrane database of systematic reviews · 2013Pooled it
- 5-year clinical outcome of the ESTOIH trial comparing the short-bite versus large-bite technique for elective midline abdominal closure.Hernia : the journal of hernias and abdominal wall surgery · 2025Trial
- Three-year follow-up analysis of the short-stitch versus long-stitch technique for elective midline abdominal closure randomized-controlled (ESTOIH) trial.Hernia : the journal of hernias and abdominal wall surgery · 2024Trial
- Effects of the short stitch technique for midline abdominal closure on incisional hernia (ESTOIH): randomized clinical trial.The British journal of surgery · 2022Trial
- Trial
- Delayed closure of open abdomen in septic patients is facilitated by combined negative pressure wound therapy and dynamic fascial suture.Surgical endoscopy · 2014Trial
- Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Development of Ciprofloxacin-Loaded Electrospun Yarns of Application Interest as Antimicrobial Surgical Suture Materials.Pharmaceutics · 2024Article
- [Incisional hernias: epidemiology, evidence and guidelines].Chirurgie (Heidelberg, Germany) · 2024Review
- ECLAPTE: Effective Closure of LAParoTomy in Emergency-2023 World Society of Emergency Surgery guidelines for the closure of laparotomy in emergency settings.World journal of emergency surgery : WJES · 2023Review
- Article
- The Best Closure Technique Without Mesh in Elective Midline Laparotomy Closure.Journal of abdominal wall surgery : JAWS · 2022Review
- Article
- Abdominal Wall Closure in Elective Midline Laparotomy: The Current Recommendations.Frontiers in surgery · 2018Article
- The History of GalaFLEX P4HB Scaffold.Aesthetic surgery journal · 2016Article
- An implantable sensor device measuring suture tension dynamics: results of developmental and experimental work.Hernia : the journal of hernias and abdominal wall surgery · 2016Article
- [Perioperative complications of the lower gastrointestinal tract : Prevention, recognition and treatment].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDifferent suture techniques and various suture materials are in use to close midline incisions after primary laparotomy. The ISSAAC study aimed to assess the safety and efficacy of the new ultra-long-term absorbable, elastic monofilament suture material MonoMax® for abdominal wall closure.
methodsThis is a single-arm, multicentre prospective study that included 150 patients undergoing a primary elective midline incision. The control group consists of 141 patients from the INSECT study who received MonoPlus® or PDS® for abdominal wall closure. The incidences of burst abdomen and wound infection until the day of discharge were defined as the primary composite endpoints. The rate of incisional hernias 1 year after surgery, the length of postoperative hospital stay and safety parameters served as secondary endpoints. The study has been registered under www.clinicaltrials.gov [NCT005725079].
resultsEleven patients in the ISSAAC study [7.3%; 95% CI = (3.9; 13.1%)] experienced wound infection or burst abdomen until the day of discharge as compared to 16 [11.3%; 95% CI = (6.6; 17.8%)] patients in the INSECT control group (p = 0.31). The length of postoperative hospital stay was comparable in both study groups. One year after surgery, incisional hernias were observed in 21 ISSAAC patients (14.0%) in contrast to 30 hernias (21.3%) in the INSECT control group.
conclusionsThe ultra-long-term absorbable, elastic monofilament suture material MonoMax® is safe and efficient for abdominal wall closure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.