ArticleNeuropharmacology2012
Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.
Article in Neuropharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025Review
- Chronic alcohol consumption alters sex-dependent BNST neuron function in rhesus macaques.Neurobiology of stress · 2024Article
- NPY-mediated synaptic plasticity in the extended amygdala prioritizes feeding during starvation.Nature communications · 2024Article
- Chronic alcohol consumption alters sex-dependent BNST neuron function in rhesus macaques.bioRxiv : the preprint server for biology · 2024Article
- Chronic stress and its effects on behavior, RNA expression of the bed nucleus of the stria terminalis, and the M-current of NPY neurons.Psychoneuroendocrinology · 2024Article
- The neurophysiological basis of stress and anxiety - comparing neuronal diversity in the bed nucleus of the stria terminalis (BNST) across species.Frontiers in cellular neuroscience · 2023Review
- Functional deletion of neuropeptide Y receptors type 2 in local synaptic networks of anteroventral BNST facilitates recall and increases return of fear.Molecular psychiatry · 2021Article
- Neuronal diversity of the amygdala and the bed nucleus of the stria terminalis.Handbook of behavioral neuroscience · 2020Article
- Multi-omics analysis identifies mitochondrial pathways associated with anxiety-related behavior.PLoS genetics · 2019Article
- Role of the Bed Nucleus of the Stria Terminalis in PTSD: Insights From Preclinical Models.Frontiers in behavioral neuroscience · 2019Review
- Physiological Profile of Neuropeptide Y-Expressing Neurons in Bed Nucleus of Stria Terminalis in Mice: State of High Excitability.Frontiers in cellular neuroscience · 2018Article
- Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development.Neurobiology of stress · 2017Review
- Genetic divergence in the transcriptional engram of chronic alcohol abuse: A laser-capture RNA-seq study of the mouse mesocorticolimbic system.Alcohol (Fayetteville, N.Y.) · 2017Article
- Review
- Structure and function of the amygdaloid NPY system: NPY Y2 receptors regulate excitatory and inhibitory synaptic transmission in the centromedial amygdala.Brain structure & function · 2016Article
- Effects of chronic ethanol exposure on neuronal function in the prefrontal cortex and extended amygdala.Neuropharmacology · 2015Article
- NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking.Nature neuroscience · 2015Article
- Neuropeptide regulation of signaling and behavior in the BNST.Molecules and cells · 2015Review
- Integrated circuits and molecular components for stress and feeding: implications for eating disorders.Genes, brain, and behavior · 2015Review
- Stress-induced glucocorticoid signaling remodels neurovascular coupling through impairment of cerebrovascular inwardly rectifying K+ channel function.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Numerous rodent and human studies have demonstrated that neuropeptide Y (NPY) is involved in the regulation of anxiety-related behaviors. In this study, we examined whether there were differences in NPY signaling between two inbred mouse strains (C57BL/6J and DBA/2J) that exhibit divergent basal and stress-induced anxiety phenotypes. We focused on the bed nucleus of the stria terminals (BNST), a structure in the extended amygdala that is important for the regulation of anxiety-like behavior and contains NPY receptors. While results from whole-cell voltage-clamp recordings and immunofluorescence histochemistry revealed no significant basal differences in NPY signaling or NPY and NPY Y2 receptor (Y2R) expression in the BNST, these measures were differentially altered by chronic restraint stress. Ten days of chronic restraint stress increased basal GABAergic transmission and decreased NPY's ability to inhibit evoked GABAergic transmission in the dorsolateral BNST (dlBNST) via Y2R in DBA/2J, but not C57BL/6J, mice. Additionally, restraint stress increased NPY and Y2R expression across subregions of the BNST of DBA/2J mice 24 h after the last stress exposure, but no changes were observed in C57BL/6J mice. Together, these results suggest that chronic restraint stress engages the NPY system and alters NPY modulation of inhibitory transmission in the dlBNST of DBA/2J mice, but not C57BL/6J mice, which may be related to increased expression of anxiety-related behaviors in this strain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.