ArticleBMC genomics2011
The phosducin-like protein PhLP1 impacts regulation of glycoside hydrolases and light response in Trichoderma reesei.
Article in BMC genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 112 citations in OpenAlex.
- RGS4 impacts carbohydrate and siderophore metabolism in Trichoderma reesei.BMC genomics · 2023Article
- Phosducin-like proteinFrontiers in microbiology · 2023Article
- Glutamine involvement in nitrogen regulation of cellulase production in fungi.Biotechnology for biofuels · 2021Article
- Understanding the Role ofJournal of fungi (Basel, Switzerland) · 2021Article
- G protein γ subunit modulates expression of plant-biomass-degrading enzyme genes and mycelial-development-related genes in Penicillium oxalicum.Applied microbiology and biotechnology · 2021Article
- cAMP activates calcium signalling via phospholipase C to regulate cellulase production in the filamentous fungus Trichoderma reesei.Biotechnology for biofuels · 2021Article
- The TOR kinase pathway is relevant for nitrogen signaling and antagonism of the mycoparasite Trichoderma atroviride.PloS one · 2021Article
- Quantitative Proteome Profiling Reveals Cellobiose-Dependent Protein Processing and Export Pathways for the Lignocellulolytic Response in Neurospora crassa.Applied and environmental microbiology · 2020Article
- Engineering ofBiotechnology for biofuels · 2020Article
- The G-protein Coupled Receptor GPR8 Regulates Secondary Metabolism inFrontiers in bioengineering and biotechnology · 2020Article
- The Kinase USK1 Regulates Cellulase Gene Expression and Secondary Metabolite Biosynthesis inFrontiers in microbiology · 2020Article
- Protein phosphatases regulate growth, development, cellulases and secondary metabolism in Trichoderma reesei.Scientific reports · 2019Article
- YPR2 is a regulator of light modulated carbon and secondary metabolism in Trichoderma reesei.BMC genomics · 2019Article
- The role of PKAc1 in gene regulation and trichodimerol production inFungal biology and biotechnology · 2019Article
- Production of cellulase byRSC advances · 2018Article
- The Duality of the MAPK Signaling Pathway in the Control of Metabolic Processes and Cellulase Production in Trichoderma reesei.Scientific reports · 2018Article
- Light-regulated promoters for tunable, temporal, and affordable control of fungal gene expression.Applied microbiology and biotechnology · 2018Review
- Regulation of plant cell wall degradation by light inFungal biology and biotechnology · 2018Review
- New Genomic Approaches to Enhance Biomass Degradation by the Industrial FungusInternational journal of genomics · 2018Review
- The Promoter Toolbox for Recombinant Gene Expression inFrontiers in bioengineering and biotechnology · 2018Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn the biotechnological workhorse Trichoderma reesei (Hypocrea jecorina) transcription of cellulase genes as well as efficiency of the secreted cellulase mixture are modulated by light. Components of the heterotrimeric G-protein pathway interact with light-dependent signals, rendering this pathway a key regulator of cellulase gene expression.
resultsAs regulators of heterotrimeric G-protein signaling, class I phosducin-like proteins, are assumed to act as co-chaperones for G-protein beta-gamma folding and exert their function in response to light in higher eukaryotes. Our results revealed light responsive transcription of the T. reesei class I phosducin-like protein gene phlp1 and indicate a light dependent function of PhLP1 also in fungi. We showed the functions of PhLP1, GNB1 and GNG1 in the same pathway, with one major output being the regulation of transcription of glycoside hydrolase genes including cellulase genes in T. reesei. We found no direct correlation between the growth rate and global regulation of glycoside hydrolases, which suggests that regulation of growth does not occur only at the level of substrate degradation efficiency.Additionally, PhLP1, GNB1 and GNG1 are all important for proper regulation of light responsiveness during long term exposure. In their absence, the amount of light regulated genes increased from 2.7% in wild type to 14% in Δphlp1. Besides from the regulation of degradative enzymes, PhLP1 was also found to impact on the transcription of genes involved in sexual development, which was in accordance with decreased efficiency of fruiting body formation in Δphlp1. The lack of GNB1 drastically diminished ascospore discharge in T. reesei.
conclusionsThe heterotrimeric G-protein pathway is crucial for the interconnection of nutrient signaling and light response of T. reesei, with the class I phosducin-like protein PhLP1, GNB1 and GNG1 acting as important nodes, which influence light responsiveness, glycoside hydrolase gene transcription and sexual development.
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