ArticleMechanisms of ageing and development2012
Effects of age and caloric restriction on mitochondrial protein oxidative damage in mice.
Article in Mechanisms of ageing and development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Age and dietary restriction modulate mitochondrial quality in quadriceps femoris muscle of male mice.Biogerontology · 2024Article
- Can static electric fields increase the activity of nitric oxide synthase and induce oxidative stress and damage of spleen?Environmental science and pollution research international · 2022Article
- Rejuvenating the Aging Heart by Enhancing the Expression of theInternational journal of molecular sciences · 2021Article
- The effect of calorie restriction on mouse skeletal muscle is sex, strain and time-dependent.Scientific reports · 2017Article
- Caloric restriction and the aging process: a critique.Free radical biology & medicine · 2014Review
- Late-onset dietary restriction modulates protein carbonylation and catalase in cerebral hemispheres of aged mice.Cellular and molecular neurobiology · 2014Article
- The effects of dietary restriction on oxidative stress in rodents.Free radical biology & medicine · 2014Review
- Calorie restriction influences key metabolic enzyme activities and markers of oxidative damage in distinct mouse liver mitochondrial sub-populations.Life sciences · 2013Article
- Involvement of redox state in the aging of Drosophila melanogaster.Antioxidants & redox signaling · 2013Review
- 4-Hydroxy-2(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by β oxidation of fatty acids in the isolated rat heart.Free radical biology & medicine · 2013Article
- Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle.Mechanisms of ageing and developmentArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The hypothesis that life-span extension by caloric restriction (CR) is contingent upon the attenuation of macromolecular oxidative damage was tested in two different strains of mice: the C57BL/6, whose life span is extended by CR, and the DBA/2, in which CR has relatively minor or no impact on longevity. Mice were fed ad libitum (AL) or restricted to 40% lesser food, starting at 4 months of age. Protein damage was measured as protein-linked adducts of 4-hydroxy-2-nonenal (HNE) and malondialdehyde (MDA) in skeletal muscle mitochondria at 6 and 23 months of age. Protein-HNE and -MDA content increased with age in C57BL/6 mice and CR significantly attenuated these augmentations. Metalloprotease 1, NADP-dependent mitochondrial malic enzyme (isoform 2) and citrate synthase were identified by mass spectroscopy to contain HNE/MDA adducts. DBA/2 mice exhibited little effect of age or CR on protein HNE/MDA content in skeletal muscle mitochondria. In contrast, protein-HNE levels in liver mitochondria showed a significant increase with age in AL-fed mice of both strains, and CR caused significant attenuation of this damage. Overall, results indicated that the age-related increase in protein oxidative damage and its abatement by CR are genotype- and tissue-specific, and not a universal phenomenon.
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