ArticleLipids in health and disease2011
The relationship between brown adipose tissue activity and neoplastic status: an (18)F-FDG PET/CT study in the tropics.
Article in Lipids in health and disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 38 citations in OpenAlex.
- Brown Adipose Tissue in Breast Cancer Evaluated by [Molecular imaging and biology · 2020Trial
- Association between brown adipose tissue activity and clinical outcomes in melanoma: a retrospective PET/CT analysis.Immuno-oncology technology · 2026Article
- Mechanistic Links Between Obesity and Breast Cancer Progression: Cellular Crosstalk, Metabolic Reprogramming and Microenvironmental Drivers.Cell biochemistry and function · 2026Review
- The effects of tissue inflammation on cancer cachexia.Biochimica et biophysica acta. Molecular basis of disease · 2026Review
- Brown adipose tissue and tumor presence: a retrospective association analysis considering the role of body mass index.Lipids in health and disease · 2025Article
- Brown adipose tissue activity on PET/CT and the course of Hodgkin lymphoma.Journal of cancer research and clinical oncology · 2025Article
- Review
- The role of brown adipose tissue in mediating healthful longevity.The journal of cardiovascular aging · 2024Article
- Body composition dynamics and impact on clinical outcome in gastric and gastro-esophageal junction cancer patients undergoing perioperative chemotherapy with the FLOT protocol.Journal of cancer research and clinical oncology · 2023Article
- Brown fat activation demonstrated on FDG PET/CT predicts survival outcome.Journal of cancer research and clinical oncology · 2023Article
- Abnormal lipid metabolism in cancer-associated cachexia and potential therapy strategy.Frontiers in oncology · 2023Review
- Brown adipocytes promote epithelial mesenchymal transition of neuroblastoma cells by inducing PPAR-γ/UCP2 expression.Adipocyte · 2022Article
- Imaging modalities for diagnosis and monitoring of cancer cachexia.EJNMMI research · 2021Review
- Brown adipose tissue and cancer progression.Skeletal radiology · 2020Article
- Brown fat does not cause cachexia in cancer patients: A large retrospective longitudinal FDG-PET/CT cohort study.PloS one · 2020Article
- Article
- Energy metabolism in cachexia.EMBO reports · 2019Review
- Preliminary investigation of brown adipose tissue assessed by PET/CT and cancer activity.Skeletal radiology · 2019Article
- Does the Poly (ADP-Ribose) Polymerase Inhibitor Veliparib Merit Further Study for Cancer-Associated Weight Loss? Observations and Conclusions from Sixty Prospectively Treated Patients.Journal of palliative medicine · 2018Article
- Implication of atypical supraclavicular F18-fluorodeoxyglucose uptake in patients with breast cancer: Association between brown adipose tissue and breast cancer.Oncology letters · 2017Article
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8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrown adipose tissue (BAT) has thermogenic potential. For its activation, cold exposure is considered a critical factor though other determinants have also been reported. The purpose of this study was to assess the relationship between neoplastic status and BAT activity by 2-deoxy-2-[(18)F]fluoro-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in people living in the tropics, where the influence of outdoor temperature was low.
methods(18)F-FDG PET/CT scans were reviewed and the total metabolic activity (TMA) of identified activated BAT quantified. The distribution and TMA of activated BAT were compared between patients with and without a cancer history. The neoplastic status of patients was scored according to their cancer history and (18)F-FDG PET/CT findings. We evaluated the relationships between the TMA of BAT and neoplastic status along with other factors: age, body mass index, fasting blood sugar, gender, and outdoor temperature.
resultsThirty of 1740 patients had activated BAT. Those with a cancer history had wider BAT distribution (p = 0.043) and a higher TMA (p = 0.028) than those without. A higher neoplastic status score was associated with a higher average TMA. Multivariate analyses showed that neoplastic status was the only factor significantly associated with the TMA of activated BAT (p = 0.016).
conclusionsNeoplastic status is a critical determinant of BAT activity in patients living in the tropics. More active neoplastic status was associated with more vigorous TMA of BAT.
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