ArticlePhotochemistry and photobiology
Pomegranate fruit extract inhibits UVB-induced inflammation and proliferation by modulating NF-κB and MAPK signaling pathways in mouse skin.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 96 citations in OpenAlex.
- Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial.Scientific reports · 2019Trial
- Mandelamide Isolated fromBiomolecules · 2026Article
- Radiation-induced esophagitis and lung injury during esophageal squamous cell cancer therapy is correlated to tumor gene expression phenotype.Toxicology research · 2025Article
- A ProprietaryAntioxidants (Basel, Switzerland) · 2025Article
- The Role of Pomegranate (Food science & nutrition · 2025Review
- The Potential of Plant Extracts Used in Cosmetic Product Applications-Antioxidants Delivery and Mechanism of Actions.Antioxidants (Basel, Switzerland) · 2024Review
- Pomegranate (Molecules (Basel, Switzerland) · 2024Review
- Opportunities and Challenges of Soy Proteins with Different Processing Applications.Antioxidants (Basel, Switzerland) · 2024Review
- Review
- Dietary Supplementation with Pomegranate and Onion Affects Lipid and Protein Oxidation in the Breast Meat, Thigh, and Liver, Cellular Stress Protein Responses, and Gene Expression of Liver Enzymes Involved in Protein Synthesis in Broilers.Foods (Basel, Switzerland) · 2023Article
- Antioxidant Phytocomplexes Extracted from Pomegranate (Antioxidants (Basel, Switzerland) · 2023Article
- Review
- The strawberry-derived permeation enhancer pelargonidin enables oral protein delivery.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins.Cancers · 2021Review
- Protective effects of halophyte complex extract against UVB-induced damage in human keratinocytes and the skin of hairless mice.Experimental and therapeutic medicine · 2021Article
- Bioactive Compounds for Skin Health: A Review.Nutrients · 2021Review
- An Update on the Role of Dietary Phytochemicals in Human Skin Cancer: New Insights into Molecular Mechanisms.Antioxidants (Basel, Switzerland) · 2020Review
- A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders.Antioxidants (Basel, Switzerland) · 2020Review
- Whole Fruit Phytochemicals Combating Skin Damage and Carcinogenesis.Translational oncology · 2020Review
- Green synthesis of silver nanoparticles at low temperature in a fast pace with unique DPPH radical scavenging and selective cytotoxicity against MCF-7 and BT-20 tumor cell lines.Biotechnology reports (Amsterdam, Netherlands) · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
There is considerable interest in the identification of natural agents capable of affording protection to skin from the adverse effects of solar ultraviolet B (UVB) radiation. Pomegranate (Punica granatum L.) fruit possesses as strong antioxidant, anti-inflammatory and antiproliferative properties. Recently, we have shown that oral feeding of pomegranate fruit extract (PFE) to mice afforded substantial protection from the adverse effects of single UVB radiation via modulation in early biomarkers of photocarcinogenesis. This study was designed to investigate the photochemopreventive effects of PFE (0.2%, wt/vol) after multiple UVB irradiations (180 mJ cm(-2), on alternative day, for a total of seven treatments) to the skin of SKH-1 hairless mice. Oral feeding of PFE to SKH-1 mice inhibited UVB-induced epidermal hyperplasia, infiltration of leukocytes, protein oxidation and lipid peroxidation. Immunoblot analysis demonstrated that oral feeding of PFE to mice inhibited UVB-induced (1) nuclear translocation and phosphorylation of nuclear factor kappa B/p65, (2) phosphorylation and degradation of IκBα, (3) activation of IKKα/ΙΚΚβ and (4) phosphorylation of mitogen-activated protein kinase proteins and c-Jun. PFE consumption also inhibited UVB-induced protein expression of (1) COX-2 and iNOS, (2) PCNA and cyclin D1 and (3) matrix metalloproteinases-2,-3 and -9 in mouse skin. Taken together, these data show that PFE consumption afforded protection to mouse skin against the adverse effects of UVB radiation by modulating UVB-induced signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.