ArticleWorld journal of gastrointestinal pathophysiology2011
Gene and cell therapy based treatment strategies for inflammatory bowel diseases.
Article in World journal of gastrointestinal pathophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Emerging Therapies in Inflammatory Bowel Disease: A Comprehensive Review.Journal of clinical medicine · 2025Review
- Contextual AI models for single-cell protein biology.Nature methods · 2024Article
- Contextual AI models for single-cell protein biology.bioRxiv : the preprint server for biology · 2024Article
- Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery.Theranostics · 2024Article
- Targeted Extracellular Vesicle Gene Therapy for Modulating Alpha-Synuclein Expression in Gut and Spinal Cord.Pharmaceutics · 2023Article
- Inflammatory bowel disease: Therapeutic limitations and prospective of the stem cell therapy.World journal of stem cells · 2020Review
- Crohn's Disease: Potential Drugs for Modulation of Autophagy.Medicina (Kaunas, Lithuania) · 2019Review
- PPAR-δ Agonist With Mesenchymal Stem Cells Induces Type II Collagen-Producing Chondrocytes in Human Arthritic Synovial Fluid.Cell transplantation · 2017Article
- Tranexamic Acid and Supportive Measures to Treat Wasting Marmoset Syndrome.Comparative medicine · 2016Article
- Serum matrix metalloproteinase 9 (MMP9) as a biochemical marker for wasting marmoset syndrome.The Journal of veterinary medical science · 2016Article
- Codelivery of DNA and siRNA via arginine-rich PEI-based polyplexes.Molecular pharmaceutics · 2015Article
- Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activation.The Journal of pharmacology and experimental therapeutics · 2015Article
- Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation.International immunopharmacology · 2014Article
- Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.The Journal of nutritional biochemistry · 2014Article
- Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling.The British journal of nutrition · 2013Article
- Murine CD4⁺CD25⁻ cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo.BMC gastroenterology · 2012Article
- Regulatory T cells in inflammatory bowel diseases and colorectal cancer.World journal of gastroenterology · 2012Review
- Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis.World journal of gastroenterology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel diseases (IBD) are a group of chronic inflammatory disorders most commonly affecting young adults. Currently available therapies can result in induction and maintenance of remission, but are not curative and have sometimes important side effects. Advances in basic research in IBD have provided new therapeutic opportunities to target the inflammatory process involved. Gene and cell therapy approaches are suitable to prevent inflammation in the gastrointestinal tract and show therefore potential in the treatment of IBD. In this review, we present the current progress in the field of both gene and cell therapy and future prospects in the context of IBD. Regarding gene therapy, we focus on viral vectors and their applications in preclinical models. The focus for cell therapy is on regulatory T lymphocytes and mesenchymal stromal cells, their potential for the treatment of IBD and the progress made in both preclinical models and clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.