Evidence map›Paper›PMID 22180768›Full record

ReviewCurrent opinion in virology2011

SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission.

Meagan Bolles, Eric Donaldson, Ralph Baric

Abstract readReview
In one paragraph

Review in Current opinion in virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  14. Interaction of Laurusides 1 and 2 with the 3C-like Protease (MInternational journal of molecular sciences · 2023
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Meagan BollesDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Eric Donaldson
Ralph Baric

Funding

Yessinia autotransporters (Yaps): Structure, function, and host responseU54AI057157 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEMPOWSKI, GREGORY D · 2003 to 2013
$91.4M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008719 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DARVILLE, TONI, DESHMUKH, MOHANISH P · 1999 to 2023
$15.1M
Broad Spectrum Neutralizing Human Abs to SARS and Related CoronavirusesR01AI085524 · NIAID · DANA-FARBER CANCER INST · PI MARASCO, WAYNE A. · 2010 to 2014
$5.4M
NIAID NIH HHS R01 AI085524NIAID NIH HHS R01 RO1AI085524NIAID NIH HHS U54 AI057157NIGMS NIH HHS T32 GM008719NIGMS NIH HHS T32GM008719
6 · The paper itself

Abstract

Most new emerging viruses are derived from strains circulating in zoonotic reservoirs. Coronaviruses, which had an established potential for cross-species transmission within domesticated animals, suddenly became relevant with the unexpected emergence of the highly pathogenic human SARS-CoV strain from zoonotic reservoirs in 2002. SARS-CoV infected approximately 8000 people worldwide before public health measures halted the epidemic. Supported by robust time-ordered sequence variation, structural biology, well-characterized patient pools, and biological data, the emergence of SARS-CoV represents one of the best-studied natural models of viral disease emergence from zoonotic sources. This review article summarizes previous and more recent advances into the molecular and structural characteristics, with particular emphasis on host–receptor interactions, that drove this remarkable virus disease outbreak in human populations.

Indexed as

Disease OutbreaksAnimalsBase SequenceChiropteraDisease ReservoirsHumansMembrane GlycoproteinsMolecular Sequence DataPhylogenyPublic HealthSevere Acute Respiratory SyndromeSevere acute respiratory syndrome-related coronavirusSpike Glycoprotein, CoronavirusViral Envelope ProteinsZoonosesMembrane GlycoproteinsSpike Glycoprotein, CoronavirusViral Envelope Proteins

Identifiers

PMID22180768
PMCPMC3237677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.