ReviewThe Yale journal of biology and medicine2011
Methods, challenges, and promise of next-generation sequencing in cancer biology.
Review in The Yale journal of biology and medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Three Grand Challenges in High Throughput Omics Technologies.Biomolecules · 2022Article
- Cutaneous Melanoma Classification: The Importance of High-Throughput Genomic Technologies.Frontiers in oncology · 2021Review
- A comparison ofTranslational lung cancer research · 2019Article
- Next Generation Sequencing in Clinical Oncology: Applications, Challenges and Promises: A Review Article.Iranian journal of public health · 2018Review
- Novel somatic mutations identified by whole-exome sequencing in muscle-invasive transitional cell carcinoma of the bladder.Oncology letters · 2016Article
- Characterization of the mutational landscape of anaplastic thyroid cancer via whole-exome sequencing.Human molecular genetics · 2015Article
- Next-generation sequencing reveals novel rare fusion events with functional implication in prostate cancer.Oncogene · 2015Article
- Lynch syndrome patients' views of and preferences for return of results following whole exome sequencing.Journal of genetic counseling · 2014Article
- CEQer: a graphical tool for copy number and allelic imbalance detection from whole-exome sequencing data.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
It is generally accepted that cancers result from the aggregation of somatic mutations. The emergence of next-generation sequencing (NGS) technologies during the past half-decade has enabled studies of cancer genomes with high sensitivity and resolution through whole-genome and whole-exome sequencing approaches, among others. This saltatory advance introduces the possibility of assembling multiple cancer genomes for analysis in a cost-effective manner. Analytical approaches are now applied to the detection of a number of somatic genome alterations, including nucleotide substitutions, insertions/deletions, copy number variations, and chromosomal rearrangements. This review provides a thorough introduction to the cancer genomics pipeline as well as a case study of these methods put into practice.
Indexed as
Identifiers
22180681PMC3238319What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.