ArticleThe Plant cell2011
GLYCOALKALOID METABOLISM1 is required for steroidal alkaloid glycosylation and prevention of phytotoxicity in tomato.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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Who cites it
98 citing papers in PubMed, 253 citations in OpenAlex.
- Quiescence of postharvest pathogens: a fungal inhibition process or an immune response of the unripe host fruit?The New phytologist · 2026Review
- Glycoalkaloid-Free Starch Potatoes Generated by CRISPR/Cas9-Mediated Mutations of Genes in the Glycoalkaloid Biosynthesis Pathway Enable More Sustainable Uses of By-Products From Starch Production.Plant biotechnology journal · 2026Article
- Complex engineering of Solanum alkaloids structural diversity in Nicotiana benthamiana.Plant biotechnology journal · 2026Article
- What metabolomics has taught us about tomato fruit ripening and quality.Journal of experimental botany · 2025Review
- Decoding steroid-derived metabolite engineering inHorticulture research · 2025Article
- Enzymatic twists evolved stereo-divergent alkaloids in the Solanaceae family.Nature communications · 2025Article
- Characterization and Potential Role of Fatty Acid-Solamine Conjugates in Plant Defense against Herbivores and Pathogens in Wild Potato Species.Journal of agricultural and food chemistry · 2025Article
- Two reductases complete steroidal glycoalkaloids biosynthesis in potato.The New phytologist · 2025Article
- Removal of toxic steroidal glycoalkaloids and bitterness in tomato is controlled by a complex epigenetic and genetic network.Science advances · 2025Article
- Incorporation of nitrogen in antinutritional Solanum alkaloid biosynthesis.Nature chemical biology · 2025Article
- Constitutive expression of full-length or partial ofFrontiers in plant science · 2025Article
- Physiological and molecular mechanisms associated with potato tuber dormancy.Journal of experimental botany · 2024Review
- A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes.Cell · 2024Article
- A distal enhancer guides the negative selection of toxic glycoalkaloids during tomato domestication.Nature communications · 2024Article
- Genome-wide methylation, transcriptome and characteristic metabolites reveal the balance between diosgenin and brassinosteroids inHorticulture research · 2024Article
- Article
- Agri-Food Waste Recycling for Healthy Remedies: Biomedical Potential of Nutraceuticals from Unripe Tomatoes (Foods (Basel, Switzerland) · 2024Review
- Functional characterization and structural basis of a reversible glycosyltransferase involves in plant chemical defence.Plant biotechnology journal · 2023Article
- Article
- Current Advances in the Biosynthesis, Metabolism, and Transcriptional Regulation of α-Tomatine in Tomato.Plants (Basel, Switzerland) · 2023Review
38 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Steroidal alkaloids (SAs) are triterpene-derived specialized metabolites found in members of the Solanaceae family that provide plants with a chemical barrier against a broad range of pathogens. Their biosynthesis involves the action of glycosyltransferases to form steroidal glycoalkaloids (SGAs). To elucidate the metabolism of SGAs in the Solanaceae family, we examined the tomato (Solanum lycopersicum) GLYCOALKALOID METABOLISM1 (GAME1) gene. Our findings imply that GAME1 is a galactosyltransferase, largely performing glycosylation of the aglycone tomatidine, resulting in SGA production in green tissues. Downregulation of GAME1 resulted in an almost 50% reduction in α-tomatine levels (the major SGA in tomato) and a large increase in its precursors (i.e., tomatidenol and tomatidine). Surprisingly, GAME1-silenced plants displayed growth retardation and severe morphological phenotypes that we suggest occur as a result of altered membrane sterol levels caused by the accumulation of the aglycone tomatidine. Together, these findings highlight the role of GAME1 in the glycosylation of SAs and in reducing the toxicity of SA metabolites to the plant cell.
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