Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2012
Preliminary findings on the interactive effects of IV ethanol and IV nicotine on human behavior and cognition: a laboratory study.
Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Effects of acute alcohol administration on working memory: a systematic review and meta-analysis.Psychopharmacology · 2022Pooled it
- The Effect of Varenicline on the Neural Processing of Fearful Faces and the Subjective Effects of Alcohol in Heavy Drinkers.Alcoholism, clinical and experimental research · 2016Trial
- Nicotine interactions with low-dose alcohol: pharmacological influences on smoking and drinking motivation.Journal of abnormal psychology · 2013Trial
- Clinical and preclinical evidence of sex differences in nicotine-induced enhancement of alcohol self-administration.Psychopharmacology · 2026Review
- Effects of nicotine-alcohol co-use on alcohol-induced blackouts and other alcohol-related consequences in college students.Psychopharmacology · 2025Article
- Prospective Association Between Tobacco Use and at-Risk Alcohol Consumption Among Swedish Adolescents: Outlining the Influence of Tobacco Product, Frequency of Use and Gender in the LoRDIA Cohort.Tobacco use insights · 2024Article
- Effects of Alcohol Intoxication on Sexual Decision-Making among Men Who Have Sex with Men (MSM): Alcohol's Influences on Self-Control Processes.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- Addiction-Related Outcomes of Nicotine and Alcohol Co-use: New Insights Following the Rise in Vaping.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022Review
- An integrated behavioural intervention combined with varenicline for heavy-drinking smokers: a randomized pilot study.Journal of smoking cessation · 2020Article
- Young adults report increased pleasure from using e-cigarettes and smoking tobacco cigarettes when drinking alcohol.Addictive behaviors · 2019Article
- Young adults report increased pleasure from smoking cigarettes when drinking alcohol but not when using marijuana.Addiction research & theory · 2018Article
- An overview of alcohol and tobacco/nicotine interactions in the human laboratory.The American journal of drug and alcohol abuse · 2017Review
- Medial Prefrontal Cortical Dopamine Responses During Operant Self-Administration of Sweetened Ethanol.Alcoholism, clinical and experimental research · 2016Article
- Ecological momentary assessment of working memory under conditions of simultaneous marijuana and tobacco use.Addiction (Abingdon, England) · 2016Article
- Current insights into the mechanisms and development of treatments for heavy drinking cigarette smokers.Current addiction reports · 2016Article
- Research on the Effects of Alcohol and Sexual Arousal on Sexual Risk in Men who have Sex with Men: Implications for HIV Prevention Interventions.AIDS and behavior · 2016Article
- Nicotine and ethanol co-use in Long-Evans rats: Stimulatory effects of perinatal exposure to a fat-rich diet.Alcohol (Fayetteville, N.Y.) · 2015Article
- Cognitive manifestations of drinking-smoking associations: preliminary findings with a cross-primed Stroop task.Drug and alcohol dependence · 2015Article
- The predicted impact of reducing the nicotine content in cigarettes on alcohol use.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2014Review
- How can we use our knowledge of alcohol-tobacco interactions to reduce alcohol use?Annual review of clinical psychology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
introductionThere are mixed reports on nicotine's effects on alcohol-induced impairment in cognitive performance and behavior in humans. The main objective of this study was to characterize the interactive effects of acute intravenous (IV) alcohol and nicotine administration on behavior and cognition in healthy nonsmokers.
methodsHealthy subjects aged 21-44 years participated in 3 test days. On each test day, they received in a double-blind randomized manner one of three IV alcohol infusion conditions using a "clamp": placebo, targeted breathalyzer of 40 mg%, or targeted breathalyzer of 80 mg%. Alcohol infusion was delivered over 20 min and lasted for 120 min. They also received both placebo and active nicotine in a fixed order delivered intravenously. Placebo nicotine was delivered first over 10 min at the timepoint when the breath alcohol was "clamped"; active nicotine (1.0 mcg/kg/min) was delivered for 10 min, 70 min after the alcohol infusion was clamped. Subjective effects of alcohol were measured using the Biphasic Alcohol Effects Scale and the Number of Drinks Scale. Cognitive inhibition and attention were measured by the Continuous Performance Task-Identical Pairs and working memory by the Rey Auditory Verbal Learning Task (RAVLT).
resultsNicotine significantly reversed subjective intoxication and sedation of alcohol at the low dose. Alcohol impaired performance on the RAVLT, and nicotine further impaired verbal learning and recall at both doses of alcohol.
conclusionsThe data showed that nicotine had an effect on subjective alcohol effects but did not reverse and actually worsened alcohol-induced deficits in memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.