Trial reportNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2012
Should all smokers use combination smoking cessation pharmacotherapy? Using novel analytic methods to detect differential treatment effects over 8 weeks of pharmacotherapy.
Trial report in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2020Pooled it
- Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology - 2019.Arquivos brasileiros de cardiologia · 2019Guideline
- Using Nicotine Gum to Assist Nondaily Smokers in Quitting: A Randomized Clinical Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Trial
- Six Month Abstinence Heterogeneity in the Best Quit Study.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Trial
- Predictors of engagement in post-discharge quitline counseling among hospitalized smokers.Journal of behavioral medicine · 2019Trial
- Toward precision smoking cessation treatment I: Moderator results from a factorial experiment.Drug and alcohol dependence · 2017Trial
- Enhancing tobacco quitline effectiveness: identifying a superior pharmacotherapy adjuvant.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2013Trial
- Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.Pharmacogenetics and genomics · 2013Trial
- Varenicline Combined With Oral Nicotine Replacement Therapy and Smartphone-Based Medication Reminders for Smoking Cessation: Feasibility Randomized Controlled Trial.JMIR formative research · 2023Article
- Antidepressants for smoking cessation.The Cochrane database of systematic reviews · 2023Review
- Socioeconomic Disadvantage and Other Risk Factors for Using Higher-Nicotine/Tar-Yield (Regular Full-Flavor) Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Transitions in Smokers' Social Networks After Quit Attempts: A Latent Transition Analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
- [Psychotherapy and pharmacotherapy for harmful tobacco use and tobacco dependency].Der Nervenarzt · 2016Article
- Beliefs, experience, and interest in pharmacotherapy among smokers with HIV.American journal of health behavior · 2014Article
- An efficient early phase 2 procedure to screen medications for efficacy in smoking cessation.Psychopharmacology · 2014Review
- A computational hypothesis for allostasis: delineation of substance dependence, conventional therapies, and alternative treatments.Frontiers in psychiatry · 2013Review
- Interventions for tobacco smoking.Annual review of clinical psychology · 2013Review
- Relations of alcohol consumption with smoking cessation milestones and tobacco dependence.Journal of consulting and clinical psychology · 2012Article
- Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success.The American journal of psychiatry · 2012Article
- DSM criteria for tobacco use disorder and tobacco withdrawal: a critique and proposed revisions for DSM-5.Addiction (Abingdon, England) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
introductionCombination pharmacotherapy for smoking cessation has been shown to be more effective than monotherapy in meta-analyses. We address the question of whether combination pharmacotherapy should be used routinely with smokers or if some types of smokers show little or no benefit from combination pharmacotherapy versus monotherapy.
methodsTwo smoking cessation trials were conducted using the same assessments and medications (bupropion, nicotine lozenge, nicotine patch, bupropion + lozenge, and patch + lozenge). Participants were smokers presenting either to primary care clinics in southeastern Wisconsin for medical treatment (Effectiveness trial, N = 1,346) or volunteering for smoking cessation treatment at smoking cessation clinics in Madison and Milwaukee, WI (Efficacy trial, N = 1,504). For each trial, decision tree analyses identified variables predicting outcome from combination pharmacotherapy versus monotherapy at the end of treatment (smoking 8 weeks after the target quit day).
resultsAll smokers tended to benefit from combination pharmacotherapy except those low in nicotine dependence (longer latency to smoke in the morning as per item 1 of the Fagerström Test of Nicotine Dependence) who also lived with a spouse or partner who smoked.
conclusionsCombination pharmacotherapy was generally more effective than monotherapy among smokers, but one group of smokers, those who were low in nicotine dependence and who lived with a smoking spouse, did not show greater benefit from using combination pharmacotherapy. Use of monotherapy with these smokers might be justified considering the expense and side effects of combination pharmacotherapy.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.