Evidence map›Paper›PMID 22180522›Full record

ArticleHIV clinical trials

Validity of self-report measures in assessing antiretroviral adherence of newly diagnosed, HAART-naïve, HIV patients.

April Buscher, Christine Hartman, Michael A Kallen, Thomas P Giordano

Registry-linked trialOpen access · bronzeAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in HIV clinical trials. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03331978 (A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans), which is not on this map. Cited by 45 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 8 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03331978 nacompletednot on this map

A Randomized Controlled Trial of an Antiretroviral Treatment Adherence Intervention for HIV+ African Americans

TypeinterventionalSponsorRANDRan2018 to 2021Enrolled306ConditionsHIV/AIDSArmsRise - Treatment Education
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 8 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

April BuscherDepartment of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Christine Hartman
Michael A Kallen
Thomas P Giordano
Baylor College of Medicine · USHealth Services Research & Development · USThe University of Texas MD Anderson Cancer Center · US

Funding

Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI KLINE, MARK W. · 1994 to 2015
$21.7M
Patient Awareness and Consumer Education Research Cente*U18HS016093 · AHRQ · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SUAREZ-ALMAZOR, MARIA E · 2006 to 2010
$4.0M
TRAINING PROGRAM FOR CLINICAL RESEARCH ON AIDST32AI007456 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI SHEARER, WILLIAM THOMAS · 1992 to 2012
$2.8M
Attitudes and Beliefs and the Steps of HIV CareR34MH074360 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI GIORDANO, THOMAS P · 2006 to 2008
$661k
AHRQ HHS U18 HS016093AHRQ HHS U18HS016093NIAID NIH HHS P30 AI036211NIAID NIH HHS P30AI036211NIAID NIH HHS T32 AI007456NIAID NIH HHS T32AI07456NIMH NIH HHS R34 MH074360NIMH NIH HHS R34MH074360
6 · The paper itself

Abstract

purposeTo compare the performance of self-report instruments assessing adherence to antiretroviral therapy (ART) in patients starting ART for the first time and in a predominately Hispanic population.

methodsOf 184 patients in a prospective observational cohort study of newly diagnosed, minority patients of low socioeconomic status, 54 were given Medication Event Monitoring System (MEMS) caps for their boosted protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI). They completed a 4-week recall visual analogue scale (VAS), the Adult AIDS Clinical Trial Group (AACTG) 4-day recall instrument, and a 1-month recall qualitative single-item measure every 3 months for up to 18 months in English or Spanish. Electronic pharmacy records recorded refill dates. Spearman correlation coefficients were calculated to compare self-report measures with MEMS data and pharmacy data.

resultsOf 46 patients with MEMS data, mean adherence was 84.7% (SD 35.6) by MEMS, 84.5% (SD 15.1) by pharmacy, 95.4% (SD 11.9) by VAS, 95.8% (SD 17.2) by AACTG, and 87.6% (SD 28.2) by qualitative single item. The correlation coefficient (CC) of VAS with MEMS was 0.37 (P < .01), and with pharmacy it was 0.34 (P < .01). The CC of the AACTG with MEMS was 0.32 (P < .01), and with pharmacy it was 0.28 (P < .01). The qualitative single item had a CC with MEMS of 0.24 (P < .01) and with pharmacy of 0.32 (P < .01). Spanish-speaking patients' VAS adherence had a CC of 0.40 (P < .01) with MEMS.

conclusionsThe VAS, AACTG, and qualitative single-item measures correlated significantly with MEMS and pharmacy data. Our data support self-administration of the VAS, even in Span-ish speakers.

Indexed as

Medication AdherencePatient ComplianceAdultAnti-HIV AgentsCohort StudiesDrug MonitoringDrug Therapy, CombinationFemaleHispanic or LatinoHIV-1HIV InfectionsHumansMaleMiddle AgedProspective StudiesReverse Transcriptase InhibitorsAnti-HIV AgentsReverse Transcriptase Inhibitors

Identifiers

PMID22180522
PMCPMC3642976
OpenAlexW2067697395

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.