ArticleHaematologica2012
Fetal iron levels are regulated by maternal and fetal Hfe genotype and dietary iron.
Article in Haematologica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Maternal Iron Status in Pregnancy and Child Health Outcomes after Birth: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Maternal iron deficiency assessed by serum ferritin and birth outcomes in mainland China.Scientific reports · 2025Article
- Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations.Cellular and molecular life sciences : CMLS · 2024Article
- Case Report: Dramatic Cholestasis Responsive to Steroids in a Newborn Homozygous for H63D HFE Variant.Frontiers in pediatrics · 2022Article
- Article
- Maternal and Early Life Iron Intake and Risk of Childhood Type 1 Diabetes: A Danish Case-Cohort Study.Nutrients · 2019Article
- Association between Neonatal Whole Blood Iron Content and Cytokines, Adipokines, and Other Immune Response Proteins.Nutrients · 2019Article
- Prenatal iron exposure and childhood type 1 diabetes.Scientific reports · 2018Article
- The iron status at birth of neonates with risk factors for developing iron deficiency: a pilot study.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Maternal iron status during pregnancy compared with neonatal iron status better predicts placental iron transporter expression in humans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Iron uptake and transport across physiological barriers.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2016Review
- The placenta: the forgotten essential organ of iron transport.Nutrition reviews · 2016Review
- Influence of iron status on risk of maternal or neonatal infection and on neonatal mortality with an emphasis on developing countries.Nutrition reviews · 2013Article
- Effect of dietary iron on fetal growth in pregnant mice.Comparative medicine · 2013Article
- Molecular insights into the regulation of iron metabolism during the prenatal and early postnatal periods.Cellular and molecular life sciences : CMLS · 2013Review
- H(+)-coupled divalent metal-ion transporter-1: functional properties, physiological roles and therapeutics.Current topics in membranes · 2012Review
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundIron metabolism during pregnancy maintains fetal iron levels at the expense of the mother. The mechanism behind this regulation is still not clear despite recent advances. Here we examine the role of maternal and fetal Hfe, its downstream signaling molecule, hepcidin and dietary iron in the regulation of placental iron transfer. DESIGN AND
methodsHfe wild-type, knockout and heterozygote dams were fed iron deficient (12.5 ppm), adequate (50 ppm) and replete (150 ppm) iron diets and mated with heterozygote males to produce pups of all genotypes. Dams and pups were sacrificed at Day 18 of gestation; serum, placenta, body and liver iron parameters were measured. Protein and mRNA levels of various iron transporter genes were determined in duodenum, liver and placenta by Western blotting and real time PCR.
resultsMaternal liver iron levels were dependent on both dietary iron intake and Hfe genotype. Increasing iron levels in the maternal diet resulted in increased total iron in the fetus, primarily in the liver. However, fetuses of Hfe-knockout mothers showed further elevation of liver iron levels, concomitant with elevated expression of Tfr1, Dmt1 and Fpn in the placenta. Hfe-knockout fetuses that express low levels of liver hepcidin accumulated more iron in their liver than wild-type fetuses due to increased ferroportin levels in the placenta.
conclusionsMaternal and fetal status, as well as dietary iron, is important in regulating iron transfer across placenta. Maternal Hfe regulates iron transfer by altering gene expression in the placenta. Fetal Hfe is important in regulating placental iron transfer by modulating fetal liver hepcidin expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.