ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Semi-solid topical formulations containing nimesulide-loaded nanocapsules showed in-vivo anti-inflammatory activity in chronic arthritis and fibrovascular tissue models.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 13 citations in OpenAlex.
- Deep-insights: Nanoengineered gel-based localized drug delivery for arthritis management.Asian journal of pharmaceutical sciences · 2025Review
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4 authors at 2 institutions in 1 country.
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Abstract
objectiveTo evaluate the anti-inflammatory activity of topical gel containing nimesulide-loaded nanocapsules using experimental models in vivo, and to compare the anti-inflammatory activity of two nimesulide preparations. MATERIALS: Male Wistar rats (200-250 g) treated with gel containing empty nanocapsules (GEN); gel containing nimesulide in the free form (GNFF) or gel containing nimesulide-loaded nanocapsules (GNN).
methodsNanoprecipitation methods were used to prepare the colloidal suspension. In-vivo experimental models of paw edema, acute and chronic arthritis, and granuloma formation were used. The gels were applied topically in all models.
resultsThe nanocapsules had an average particle size of 344.6 nm ± 4.33 and a polydispersity index of 0.251 ± 0.002. The models of acute inflammation (paw edema and arthritis) showed that GNFF and GNN were able to inhibit the inflammatory process with similar efficacy. Moreover, nanoencapsulation significantly increased the anti-inflammatory activity of nimesulide in two chronic inflammation models (chronic arthritis and granuloma). The GNFF- and GNN-induced inhibition of inflammation in the chronic arthritis model were 27.75 and 81.5%, respectively. Similarly, GNFF and GNN reduced granuloma formation by 2.82 and 36.66%.
conclusionNanoencapsulation increased the anti-inflammatory activity of topical nimesulide in chronic inflammation models.
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